{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:16:27Z","timestamp":1787238987914,"version":"build-2736575974"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1186915"],"award-info":[{"award-number":["1186915"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe variations in ganglion cell\u2013inner plexiform layer (GCIPL) thickness in a healthy cohort from widefield optical coherence tomography (OCT) scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Widefield OCT scans spanning 55\u00b0\u2009\u00d7\u200945\u00b0 were acquired from 470 healthy eyes. The GCIPL was automatically segmented using deep learning methods. Thickness measurements were extracted after correction for warpage and retinal tilt. Multiple linear regression analysis was applied to discern trends between global GCIPL thickness and age, axial length and sex. To further characterise age\u2010related change, hierarchical and two\u2010step cluster algorithms were applied to identify locations sharing similar ageing properties, and rates of change were quantified using regression analyses with data pooled by cluster analysis outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Declines in widefield GCIPL thickness with age, increasing axial length and female sex were observed (parameter estimates \u22120.053, \u22120.436 and\u2009\u22120.464,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values &lt;0.001, &lt;0.001 and 0.02, respectively). Cluster analyses revealed concentric, slightly nasally displaced, horseshoe patterns of age\u2010related change in the GCIPL, with up to four statistically distinct clusters outside the macula. Linear regression analyses revealed significant ageing decline in GCIPL thickness across all clusters, with faster rates of change observed at central locations when expressed as absolute (slope\u2009=\u2009\u22120.19 centrally vs. \u22120.04 to \u22120.12 peripherally) and percentage rates of change (slope\u2009=\u2009\u22120.001 centrally vs. \u22120.0005 peripherally).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Normative variations in GCIPL thickness from widefield OCT with age, axial length and sex were noted, highlighting factors worth considering in further developments. Widefield OCT has promising potential to facilitate quantitative detection of abnormal GCIPL outside standard fields of view.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13255","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:02:01Z","timestamp":1700766121000},"page":"457-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterisation of the normal human ganglion cell\u2013inner plexiform layer using widefield optical coherence tomography"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-5138","authenticated-orcid":false,"given":"Janelle","family":"Tong","sequence":"first","affiliation":[{"name":"Centre for Eye Health University of New South Wales  Sydney New South Wales Australia"},{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales 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