{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:31Z","timestamp":1787015851146,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010383","name":"Topcon Europe Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate the short\u2010term effects of cyclopentolate and tropicamide eyedrops on choroidal thickness (ChT) in myopic children using placebo or low\u2010dose atropine eyedrops.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The analysis included 242 myopic individuals (7\u201319\u2009years) enrolled in two randomised placebo\u2010controlled clinical trials of low\u2010dose atropine eyedrops. Cycloplegia was induced using either one drop of 1% cyclopentolate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009161), two drops of 1% cyclopentolate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932) or two drops of 1% tropicamide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949). ChT measurements were taken using swept\u2010source optical coherence tomography before and 30\u2009min after administering the cycloplegic eye drops. A subset of 51 participants underwent test\u2013retest measurements prior to cycloplegia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean changes in subfoveal ChT after two drops of tropicamide and one and two drops of cyclopentolate were\u2009\u22122.5\u2009\u03bcm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10), \u22124.3\u2009\u03bcm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and\u2009\u22129.6\u2009\u03bcm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively. Subfoveal ChT changes after one and two drops of cyclopentolate were significantly greater than the test\u2013retest changes (test\u2013retest mean change: \u22123.1\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while the tropicamide group was not significantly different (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.64). Choroidal thinning post\u2010cyclopentolate was not significantly different between atropine and placebo treatment groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for all macular locations). The coefficient of repeatability (CoR) in the tropicamide group (range: 8.2\u201314.4\u2009\u03bcm) was similar to test\u2013retest (range: 7.5\u201312.2\u2009\u03bcm), whereas greater CoR values were observed in the cyclopentolate groups (one drop: range: 10.8\u201315.3\u2009\u03bcm; two drops: range: 12.2\u201324.6\u2009\u03bcm).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cyclopentolate eye drops caused dose\u2010dependent choroidal thinning and increased variation in pre\u2010 to post\u2010cycloplegia measurements compared with test\u2013retest variability, whereas tropicamide did not. These findings have practical implications for ChT measurements when cyclopentolate is used, particularly for successive measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13256","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T01:53:05Z","timestamp":1701395585000},"page":"280-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Short\u2010term effects of cyclopentolate and tropicamide eye drops on macular choroidal thickness in myopic children"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-7992","authenticated-orcid":false,"given":"Emmanuel","family":"Kobia\u2010Acquah","sequence":"first","affiliation":[{"name":"Centre for Eye Research Ireland, Environmental Sustainability and Health Institute Technological University Dublin  Dublin 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