{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:49:51Z","timestamp":1774446591024,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007515","name":"Universidad de Valladolid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the impact of 3\u2009months of orthokeratology (ortho\u2010k) contact lenses (CLs) for myopia correction on the corneoscleral profile, as changes in scleral geometry could serve as indirect evidence of alteration in the corneal biomechanical properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty subjects (40 eyes) were recruited to wear ortho\u2010k lenses overnight; however, after discontinuation (two CL fractures, one under\u2010correction and two non\u2010serious adverse events), 16 subjects (31 eyes) finished a 3\u2010month follow\u2010up. Corneoscleral topographies were acquired using the Eye Surface Profiler (ESP) system before and after 3\u2009months of lens wear. Steep (SimKs) and flat (SimKf) simulated keratometry and scleral sagittal height measurements for 13\u2010, 14\u2010 and 15\u2010mm chord lengths were automatically calculated by the ESP software. Additionally, sagittal height and slope were calculated in polar format from 21 radii (0\u201310\u2009mm from the corneal apex) at 12 angles (0\u2013330\u00b0). Linear mixed models were fitted to determine the differences between visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SimKs and SimKf were increased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.02). The sagittal height in polar format increased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046) at a radius of 2.5\u2009mm for 150\u00b0, 180\u00b0, 210\u00b0 and 240\u00b0 orientations and at a radius of 3.0\u2009mm for 210\u00b0. Additionally, the slope in polar format significantly decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.04) at radii ranges of 0.0\u20130.5, 0.5\u20131.0 and 1.0\u20131.5 mm\u00a0for multiple angles and at a radii range of 5.0\u20135.5 mm\u00a0for 90\u00b0. It also increased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.045) at a radii range of 1.5\u20132.0 mm\u00a0for 30\u00b0 and at radii ranges of 2.0\u20132.5, 2.5\u20133.0 and 3.0\u20133.5 mm\u00a0for multiple angles. No significant changes were found for any parameter measured from the scleral area.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Three months of overnight ortho\u2010k lens wear changed the central and mid\u2010peripheral corneal geometry as expected, maintaining the peripheral cornea and the surrounding sclera stability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13279","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T05:30:18Z","timestamp":1705642218000},"page":"757-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Orthokeratology effect on the corneoscleral profile: Beyond the bull's eye"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3765-2478","authenticated-orcid":false,"given":"Elena","family":"Mart\u00ednez\u2010Plaza","sequence":"first","affiliation":[{"name":"Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy University of Alicante  Alicante Spain"},{"name":"University of Valladolid  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6017-8618","authenticated-orcid":false,"given":"Alberto","family":"L\u00f3pez\u2010de\u00a0la\u00a0Rosa","sequence":"additional","affiliation":[{"name":"Department of Theoretical Physics, Atomic and Optics University of Valladolid  Valladolid Spain"},{"name":"Instituto de Oftalmobiolog\u00eda Aplicada (IOBA) University of Valladolid  Valladolid 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