{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T21:54:52Z","timestamp":1782597292488,"version":"3.54.5"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013968","name":"Johnson and Johnson Vision Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate differences in key clinical parameters between asymptomatic and highly symptomatic soft contact lens (CL) wearers after 14\u2009h of wear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this pilot investigation,\n                      <jats:italic>Phase 1<\/jats:italic>\n                      identified asymptomatic (CLDEQ\u20108 score\u2009\u2264\u20097) and highly symptomatic (CLDEQ\u20108 score\u2009\u2265\u200920) subjects after fitting with\n                      <jats:italic>nelfilcon A CLs<\/jats:italic>\n                      .\n                      <jats:italic>Phase 2<\/jats:italic>\n                      investigated the following over a single\n                      <jats:italic>nelfilcon<\/jats:italic>\n                      A CL\u2010wearing day (14\u2009\u00b1\u20092\u2009h): blinking characteristics, tear meniscus height (TMH), non\u2010invasive tear break\u2010up time (NIBUT), tear film osmolarity and eyelid margin staining. Parameters for the two groups were compared using linear mixed models and post\u2010hoc testing. The relationship between comfort scores and the clinical parameters was also investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 161 and 42 subjects were enrolled into\n                      <jats:italic>Phase<\/jats:italic>\n                      1 and 2, respectively. Twenty\u2010five asymptomatic and 17 symptomatic subjects completed\n                      <jats:italic>Phase 2<\/jats:italic>\n                      . Lower eyelid TMH was decreased after 14\u2009h in symptomatic compared with asymptomatic subjects (least square mean [LSM] difference\u2009\u22120.04\u2009mm, 95% CI: \u22120.07, \u22120.01). Osmolarity was lower in symptomatic than in asymptomatic subjects at fitting (LSM difference\u2009\u22129.89, 95% CI: \u221218.91, \u22120.86). Upper eyelid margin staining was greater after 14\u2009h in symptomatic than in asymptomatic subjects (LSM difference 0.53, 95% CI: 0.01, 1.05) and greater after 14\u2009h than baseline in the symptomatic group (LSM difference 0.61, 95% CI: 0.16, 1.07). There was a significant relationship between comfort and upper eyelid margin staining (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.40, 95% CI: \u22120.63, \u22120.11) and blink rate (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.31, 95% CI: \u22120.57, \u22120.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The potential parameters most effective in differentiating asymptomatic from symptomatic wearers were upper eyelid margin staining and lower TMH. The parameter with the strongest relationship to comfort was upper eyelid margin staining, where higher comfort scores were associated with lower levels of staining.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13305","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T10:08:57Z","timestamp":1711620537000},"page":"704-717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["End\u2010of\u2010day assessment of asymptomatic versus highly symptomatic soft contact lens wearers"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4101-376X","authenticated-orcid":false,"given":"Carole","family":"Maldonado\u2010Codina","sequence":"first","affiliation":[{"name":"Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-1067","authenticated-orcid":false,"given":"Maria","family":"Navascues\u2010Cornago","sequence":"additional","affiliation":[{"name":"Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-3594","authenticated-orcid":false,"given":"Sarah L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-8567","authenticated-orcid":false,"given":"Michael L.","family":"Read","sequence":"additional","affiliation":[{"name":"Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-0905","authenticated-orcid":false,"given":"Carol","family":"Lakkis","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Vision Care, Inc.  Jacksonville Florida USA"},{"name":"iBiomedical Consulting Pty Ltd  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-8169","authenticated-orcid":false,"given":"Philip B.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12020261"},{"key":"e_1_2_12_3_1","article-title":"A look at the latest lenses on the market and their modalities","volume":"14","author":"Quint J","year":"2022","journal-title":"Optometry Times"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2010.08.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200108000-00011"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000927"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2005.12.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-8967(01)00040-2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e318271caf4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2002.00066.x"},{"key":"e_1_2_12_11_1","first-page":"220","article-title":"A study of contact lens failures","volume":"64","author":"Schlanger JL","year":"1993","journal-title":"J Am Optom Assoc"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13074"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2020.08.007"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2020.02.010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135323"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12318"},{"key":"e_1_2_12_17_1","first-page":"28","article-title":"International contact lens prescribing in 2022","volume":"38","author":"Morgan PB","year":"2023","journal-title":"Contact Lens Spectrum"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000102"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.12968\/opti.2022.2.8876"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13189"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318269c90d"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2016.04.005"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12694"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181d951df"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2022.101596"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(77)90916-3"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-0484(98)80035-0"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12901"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-1961-4"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ICL.0000140910.03095.FA"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181ba0cb2"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2006.12.002"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2015.01.003"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6841"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2012.00922.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1198\/000313001300339897"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.10.049"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S39104"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24690"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318194e962"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icl.0000224551.58399.9a"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31829962ec"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5780"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0685"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2794"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13040859"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2020.08.007"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000134"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2017.10.004"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2005.12.006"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2011.00647.x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-199910000-00021"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000866"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2023.101850"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1392"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.001"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/00140068-200301001-00028"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2010.01.004"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1504"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.03.006"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2017.09.011"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2022.101773"},{"key":"e_1_2_12_63_1","first-page":"211","article-title":"Lid\u2010wiper epitheliopathy and dry\u2010eye symptoms in contact lens wearers","volume":"28","author":"Korb DR","year":"2002","journal-title":"CLAO J"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11249\u2010020\u201001344\u20103"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182254009"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02482.x"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotri.2017.04.003"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.08.009"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000865"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002192"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000919"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2016.04.004"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2013.02.013"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000878"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e3181d94e82"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181888909"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.13305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:24:16Z","timestamp":1767785056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opo.13305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":75,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/opo.13305"],"URL":"https:\/\/doi.org\/10.1111\/opo.13305","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]},"assertion":[{"value":"2023-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}