{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:48:13Z","timestamp":1791402493057,"version":"4.3.3"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N013166\/1"],"award-info":[{"award-number":["MR\/N013166\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Research assuming linearity has concluded that corneal biomechanics are compromised in high myopia. We investigated whether this assumption was appropriate and re\u2010examined these associations across different levels of myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Myopic (spherical equivalent refraction, SER\u2009\u2264\u2009\u22120.50\u2009D) eyes of 10,488 adults aged 40\u201369\u2009years without any history of systemic and ocular conditions were identified in the UK Biobank. Ordinary least squares (OLS) regression was employed to test the linear association between corneal hysteresis (CH) or corneal resistance factor (CRF), separately, and SER while controlling for age, sex, corneal radius and intraocular pressure. Quantile regression (QR) was used to test the same set of associations across 49 equally spaced conditional quantiles of SER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In OLS regression, each standard deviation (SD) decrease in CH and CRF was associated with 0.08\u2009D (95% CI: 0.04\u20130.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 0.10\u2009D (95% CI: 0.04\u20130.15;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) higher myopia, respectively. However, residual analysis indicated that the linearity assumption was violated. QR revealed no evidence of a significant association between CH\/CRF and SER in low myopia, but a significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) positive association became evident from \u22122.78\u2009D (0.06 and 0.08\u2009D higher myopia per SD decrease in CH and CRF). The magnitude of association increased exponentially with increasing myopia: in the \u22125.03\u2009D quantile, every SD decrease in CH and CRF was associated with 0.17\u2009D (95% CI: 0.08\u20130.25;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 0.21\u2009D (95% CI: 0.10\u20130.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) higher myopia. In the \u22128.63\u2009D quantile, this further increased to 0.54\u2009D (95% CI: 0.33\u20130.76;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 0.67\u2009D (95% CI: 0.41\u20130.93;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) higher myopia per SD decrease in CH and CRF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Corneal biomechanics appeared compromised from around \u22123.00\u2009D. These changes were observed to be exponential with increasing myopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13313","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:48:08Z","timestamp":1712058488000},"page":"977-986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Corneal biomechanics are not exclusively compromised in high myopia"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-7363","authenticated-orcid":false,"given":"Fabian","family":"Yii","sequence":"first","affiliation":[{"name":"Centre for Clinical Brain Sciences The University of Edinburgh  Edinburgh UK"},{"name":"Curle Ophthalmology Laboratory, Institute for Regeneration and Repair The University of Edinburgh  Edinburgh 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