{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:14:11Z","timestamp":1789827251061,"version":"4.0.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070929"],"award-info":[{"award-number":["82070929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the microcirculatory characteristics of the dome\u2010shaped macula (DSM), its complications in highly myopic eyes and to explore the factors associated with a DSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional case\u2013control study included a total of 98 subjects (98 eyes): 49 eyes with DSM and 49 eyes without DSM. The axial length (AL) of the myopic eyes was matched 1:1 to eliminate the effect of AL differences on the results. Choroidal (CT) and scleral thickness (ST) and other structural parameters were assessed by swept\u2010source optical coherence tomography (SS\u2010OCT). OCT angiography was used to measure microcirculatory parameters in highly myopic eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Subjects with DSM had thinner subfoveal choroidal thickness (46.01\u2009\u00b1\u200913.25 vs. 81.62\u2009\u00b1\u200948.26\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), thicker subfoveal scleral thickness (SFST; 331.93\u2009\u00b1\u200979.87 vs. 238.74\u2009\u00b1\u200970.96\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and thinner foveal CT (66.86\u2009\u00b1\u200924.65 vs. 107.85\u2009\u00b1\u200952.65\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to subjects without DSM. The foveal choroidal perfusion area (0.72\u2009\u00b1\u20090.04 vs. 0.76\u2009\u00b1\u20090.04\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and foveal choroidal vascularity index (0.15\u2009\u00b1\u20090.04 vs. 0.33\u2009\u00b1\u20090.14;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significantly lower in eyes with DSM. Retinoschisis (81.6% vs. 38.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) was more common in eyes with DSM. Eyes with horizontal DSM had worse best\u2010corrected logMAR visual acuity than eyes with round DSM (0.34\u2009\u00b1\u20090.22 vs. 0.23\u2009\u00b1\u20090.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). DSM height (98.95\u2009\u00b1\u200965.17 vs. 104.63\u2009\u00b1\u200944.62\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) was lower in the horizontal DSM. SFST (OR\u2009=\u20091.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and foveal choroidal vascularity index (OR\u2009=\u20090.711,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) were significantly associated with DSM. DSM width (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), foveal choroidal perfusion area (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), foveal choriocapillaris perfusion area (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and parafoveal choroidal vascularity index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) were the most significantly associated factors with DSM height.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The microcirculatory characteristics of eyes with DSM differed from those without DSM. Microcirculatory abnormalities were significantly associated with a DSM. The height of the DSM was associated with decreased blood perfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13314","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T02:05:44Z","timestamp":1714442744000},"page":"987-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the microcirculation of the dome\u2010shaped macula and its complications in adults with highly myopic eyes by swept\u2010source optical coherence tomography angiography"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6252-4120","authenticated-orcid":false,"given":"Haoru","family":"Li","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin 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Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin 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