{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:24:34Z","timestamp":1774308274401,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Soft contact lenses may be a good alternative for early\u2010stage keratoconus (KC) patients who do not tolerate rigid gas permeable (RGP) lenses due to ocular discomfort or complications. This prospective study compared outcomes obtained after 2\u2009weeks of wearing two types of soft silicone hydrogel contact lenses for keratoconus that varied in their diameter and central thickness (cc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with Amsler\u2013Krumeich grades I or II KC were fitted with small\u2010diameter (14.2 or 14.8\u2009mm) SoftK (SD\u2010SoftK, cc\u2009=\u20090.48\u2009mm) and large\u2010diameter (17\u2009mm) SoftK (LD\u2010SoftK, cc\u2009=\u20090.60\u2009mm) lenses, each worn for 2\u2009weeks in a crossover design. Low (10%;10VA) and high (100%;100VA) contrast visual acuity, contrast sensitivity (CS, Pelli\u2010Robson), higher order aberrations (HOAs, Visionix Vx130), the number of trial lens modifications during fitting and the subjectively preferred lens were compared using Friedman tests with post\u2010hoc analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty eyes (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200920, 10 males, mean age: 39.0\u2009\u00b1\u20099.9\u2009years, range: 23\u201355\u2009years) were examined. Their habitual median (interquartile1, interquartile3) 10VA (LogMAR), 100VA (LogMAR) and CS (LogCS) were 0.52 (0.30, 0.50), 0.14 (0.10, 0.15) and 1.35 (1.35, 1.50), respectively. For the SD\u2010SoftK condition, the values were 0.23 (0.17, 0.30), 0.02 (0.00, 0.05) and 1.50 (1.50, 1.65), respectively. For the LD\u2010SoftK condition, the respective values were 0.36 (0.27, 0.44), 0.09 (0.05, 0.13) and 1.50 (1.50, 1.60). SD\u2010SoftK lenses significantly improved 10VA compared with habitual and LD\u2010SoftK. SD\u2010SoftK also significantly improved CS compared with habitual, but not LD\u2010SoftK. LD\u2010SoftK significantly improved spherical aberration compared with uncorrected (0.03\u2009\u00b1\u20090.10\u2009\u03bc vs. 0.07\u2009\u00b1\u20090.13\u2009\u03bc) but not SD\u2010SoftK (0.04\u2009\u00b1\u20090.07\u2009\u03bc). Both lenses required a mean of 1.5 modifications prior to final lens fitting. Fewer adverse events were seen with SD\u2010SoftK (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20093) compared with LD\u2010SoftK (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20098), and 75% of participants preferred SD\u2010SoftK lenses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SD\u2010SoftK lenses were preferred by 75% of subjects, were associated with fewer adverse events and significantly improved 10VA compared with LD\u2010SoftK lenses. SD\u2010SoftK lenses also significantly improved CS compared with the habitual correction, but this did not differ significantly from the LD\u2010SoftK lenses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13331","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T02:14:26Z","timestamp":1716430466000},"page":"884-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of large\u2010diameter and small\u2010diameter SoftK specialty contact lenses for early\u2010stage keratoconus"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0443-5874","authenticated-orcid":false,"given":"Eyal","family":"Gal","sequence":"first","affiliation":[{"name":"Department of Optometry and Vision Science Hadassah Academic College  Jerusalem Israel"},{"name":"Universitat Polit\u00e8cnica de Catalunya University Vision Centre  Terrassa, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Gispets","sequence":"additional","affiliation":[{"name":"Universitat Polit\u00e8cnica de Catalunya University Vision Centre  Terrassa, Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meira","family":"Zyroff","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Science Hadassah Academic College  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrat","family":"Netanya","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Science Hadassah Academic College  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-3528","authenticated-orcid":false,"given":"Liat","family":"Gantz","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Science Hadassah Academic College  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00119-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90094-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.08.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10025-1002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12300"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2020.07.17"},{"key":"e_1_2_11_8_1","first-page":"2537","article-title":"Baseline findings in the collaborative longitudinal evaluation of keratoconus (CLEK) study","volume":"39","author":"Zadnik K","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CLAE.2022.101794"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2007.03.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12237"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12133"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2017.09.020"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0348"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000183"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icl.0000179707.85290.f4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30123-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001843"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201031008\u20101"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001645"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.1999.00420.x-i1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318194e951"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517690822"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492013000600016"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11743"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2018.03.004"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31522"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2011.00889.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.22336\/rjo.2020.45"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1212314"},{"key":"e_1_2_11_33_1","first-page":"276","article-title":"Vom richtigen umgang mit dem crossover\u2010design in klinischen studien: Teil 18 der serie zur bewertung wissenschaftlicher publikationen","volume":"109","author":"Wellek S","year":"2012","journal-title":"Dtsch Arztebl Int"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.13331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:24:21Z","timestamp":1767785061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opo.13331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/opo.13331"],"URL":"https:\/\/doi.org\/10.1111\/opo.13331","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"assertion":[{"value":"2024-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}