{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:29:32Z","timestamp":1790792972456,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Genetic aetiology is suspected in the development of early\u2010onset high myopia (spherical equivalent refractive error [SER]\u2009\u2264\u22126.00 D at \u22646\u2009years of age), considering that the role of environmental factors in inducing high myopia is improbable at an early age. Therefore, we aimed to understand if early\u2010onset high myopia is associated with parental myopia in a clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted in which information about demographics, age of apparent onset of myopia, refractive error, axial length, number of myopic parents, time spent outdoors and time spent on near\u2010work was obtained from electronic medical records (EMR). It included 195 myopic individuals categorised into (1) Early\u2010onset high myopes (EOHM): SER\u2009\u2264\u2009\u22126.00 D with age of presentation \u22646\u2009years, (2) Early\u2010onset low myopes (EOLM): SER\u2009&gt;\u2009\u22126.00 D with age of apparent onset \u22646\u2009years, (3) Late\u2010onset high myopes (LOHM): SER\u2009\u2264\u2009\u22126.00 D with age of presentation and age of apparent onset &gt;6\u2009years and (4) Late\u2010onset low myopes (LOLM): SER\u2009&gt;\u2009\u22126.00 D with age of apparent onset &gt;6\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 63% of individuals were found to have parental myopia. The proportion of individuals with EOHM, EOLM, LOHM and LOLM with parental myopia was 57%, 74%, 53% and 64%, respectively. After adjustment for age, gender and environmental factors, the odds of development of EOHM (Odds ratio: 0.78, 95% confidence interval: 0.25\u20132.48), EOLM (1.54, 0.65\u20133.67) or LOHM (0.70, 0.30\u20131.65) were similar in the presence of myopic parents, when compared with LOLM. The SER and axial length did not differ based on the number of myopic parents in any of these categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This retrospective analysis reveals that the presence of parental myopia, which was self\u2010reported, did not induce additional risk for early\u2010onset high myopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13341","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T01:54:17Z","timestamp":1716861257000},"page":"1270-1278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Link between parental myopia and early\u2010onset high myopia: Insights from a clinical retrospective analysis"],"prefix":"10.1007","volume":"44","author":[{"given":"Sruthi","family":"Chamarty","sequence":"first","affiliation":[{"name":"Myopia Research Lab, Prof. Brien Holden Eye Research Centre L V Prasad Eye Institute  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreena","family":"Kamalon","sequence":"additional","affiliation":[{"name":"Brien Holden Institute of Optometry and Vision Sciences L V Prasad Eye Institute  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Madishetti","sequence":"additional","affiliation":[{"name":"Brien Holden Institute of Optometry and Vision Sciences L V Prasad Eye Institute  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-2178","authenticated-orcid":false,"given":"Pavan K.","family":"Verkicharla","sequence":"additional","affiliation":[{"name":"Myopia Research Lab, Prof. Brien Holden Eye Research Centre 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