{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:11:00Z","timestamp":1781104260226,"version":"3.54.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the repeatability of retinal and choroidal optical coherence tomography angiography (OCT\u2010A) indices among healthy children and compare it to healthy young adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective study captured 3\u2009mm\u2009\u00d7\u20093\u2009mm and 6\u2009mm\u2009\u00d7\u20096\u2009mm macular OCT\u2010A scans including superficial and deep retinal layers, choriocapillaris and deep choroid over two visits, 1\u2009week apart at approximately the same time of day, for 22 healthy adults (18\u201330\u2009years) and 21 children (6\u201315\u2009years). Magnification and projection\u2010artefact corrected indices extracted using a custom image analysis program and individual biometry were compared between visits using Bland\u2013Altman analysis and intraclass correlation (ICC). Retinal indices included foveal avascular zone metrics, perfusion and vessel density and choroidal indices included choriocapillaris flow deficit metrics and deep choroid perfusion density, in the foveal, parafoveal and perifoveal regions. Repeatability between adults and children was compared with\n                      <jats:italic>F<\/jats:italic>\n                      \u2010test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bland\u2013Altman analysis showed that the mean differences between repeated OCT\u2010A indices were not significantly different from zero for either of the zones, layers and scan sizes in the two age groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) except for foveal vessel density and foveal avascular zone perimeter (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04 for both) of 6\u2010mm\u2010deep retinal layer scans. The ICC ranged between 0.67 and 0.99. Significantly higher variability between visits (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in the indices was noted among adults than children, especially for choroidal indices of larger scan size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The retinal and choroidal OCT\u2010A indices in the foveal, parafoveal and perifoveal zones were repeatable in healthy children except for the foveal vessel density and foveal avascular zone perimeter of the 6\u2010mm\u2010deep retinal layer, which exhibited statistically borderline differences between visits. The adult group showed more variability between visits compared to children, especially in the larger scan size for choroidal OCT\u2010A indices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13357","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T06:47:38Z","timestamp":1719298058000},"page":"1114-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Repeatability of retinal and choroidal optical coherence tomography angiography indices in healthy children and young adults"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-5501","authenticated-orcid":false,"given":"Barsha","family":"Lal","sequence":"first","affiliation":[{"name":"Centre for Vision and Eye Research, Optometry and Vision Science Queensland University of Technology, Kelvin Grove  Brisbane Queensland 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