{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:28:48Z","timestamp":1787164128292,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate axial elongation (AE) and changes in relative peripheral refraction (RPR) in anisomyopic children undergoing orthokeratology (ortho\u2010k).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bilateral anisomyopic children, 7\u201312\u2009years of age, were treated with ortho\u2010k. Axial length (AL) and RPR, from 30\u00b0 nasal (N30\u00b0) to 30\u00b0 temporal (T30\u00b0), were measured at baseline and every 6\u2009months over the study period. AE, changes in RPR and changes in the interocular AL difference were determined over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010six of the 33 subjects completed the 2\u2010year study. The AE of the higher myopic (HM)\u00a0eyes (at least 1.50 D more myopia than the other eye) (0.26\u2009\u00b1\u20090.29\u2009mm) was significantly smaller than for the less myopic (LM)\u00a0eyes (0.50\u2009\u00b1\u20090.27\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), leading to a reduction in the interocular difference in AL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Baseline RPR measurements in the HM eyes were relatively more hyperopic at T30\u00b0, N20\u00b0 and N30\u00b0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.02) and greater myopic shifts were observed at T20\u00b0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), T30\u00b0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), N20\u00b0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and N30\u00b0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) after lens wear. After 2\u2009years of ortho\u2010k lens wear, temporal\u2013nasal asymmetry increased significantly, being more myopic at the temporal locations in both eyes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while AE was associated with the change in RPR at N20\u00b0 (\u03b2\u2009=\u20090.134,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). The interocular difference in AE was also positively associated with the interocular difference in RPR change at N30\u00b0 (\u03b2\u2009=\u20090.111,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ortho\u2010k slowed AE in bilateral anisomyopia, with slower growth in the HM eyes leading to a reduction in interocular AL differences. After ortho\u2010k, RPR changed from hyperopia to myopia, with greater changes induced in the HM eyes, and slower AE was associated with a more myopic shift in RPR, especially in the nasal field of both eyes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13365","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T07:10:43Z","timestamp":1720681843000},"page":"1261-1269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anisomyopia and orthokeratology for myopia control \u2013 Axial elongation and relative peripheral refraction"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8215-2806","authenticated-orcid":false,"given":"Jianglan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Optometry and Visual Science, West China School of Medicine Sichuan University  Chengdu 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