{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:45:31Z","timestamp":1790300731871,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>It is common to hear talk of \u2018responders\u2019 and \u2018non\u2010responders\u2019 with respect to myopia control interventions. We consider the reality of distinguishing these sub\u2010groups using data from the first year of the Low\u2010concentration Atropine for Myopia Progression (LAMP) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The first year of the LAMP study was a robustly designed, placebo\u2010controlled trial of three different low concentrations of atropine using a large sample size (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009&gt;\u2009100 randomised to each group). The authors subsequently published mean axial elongation and myopia progression rates by age group. We used these data to calculate efficacy in terms of both absolute reduction in myopic progression and absolute reduction in axial elongation for each of the different atropine concentrations at each age group. We then compared these efficacy data to the overall progression for each of the two progression metrics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plotting efficacy as a function of overall myopia progression and axial elongation for each of the different atropine concentrations demonstrates the invariant nature of efficacy, in terms of clinically meaningful reduction in progression, despite a substantial range of underlying overall progression. That is, faster progressors\u2014the so\u2010called non\u2010responders\u2014achieved similar reduction in axial elongation and myopia progression as the slower progressors\u2014the so\u2010called responders\u2014within the various atropine treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of the terms, responders and non\u2010responders, during myopia progression interventions is not supported by evidence. Those designated as such may simply be slower or faster progressors, who, on average achieve the same benefit from treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13379","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T04:29:48Z","timestamp":1725424188000},"page":"1363-1367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Can we really distinguish \u2018responders\u2019 from \u2018non\u2010responders\u2019 to myopia control interventions?"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-6435","authenticated-orcid":false,"given":"Noel A.","family":"Brennan","sequence":"first","affiliation":[{"name":"Johnson &amp; Johnson  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex D.","family":"Nixon","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-0759","authenticated-orcid":false,"given":"Xu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-3720","authenticated-orcid":false,"given":"Mark A.","family":"Bullimore","sequence":"additional","affiliation":[{"name":"College of Optometry University of Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.4.49"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.04.032"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.4009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201042108\u2010y"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.035"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.04.022"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.05.011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.06.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.24162"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-023-02718-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-023-02723-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.12.036"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001873"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2020.11.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13042"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14289"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13162"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001883"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.13.12"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100923"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.05.029"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.02.020"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000002176"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.024"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12614"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000990"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000002119"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25967"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.07.004"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.064212"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.13379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:24:00Z","timestamp":1767785040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opo.13379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/opo.13379"],"URL":"https:\/\/doi.org\/10.1111\/opo.13379","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"2024-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}