{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:48:28Z","timestamp":1790081308584,"version":"4.0.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001793","name":"Queensland University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To quantify the magnitude and recovery of central and limbal corneal oedema induced by short\u2010term unilateral eyelid closure without contact lens wear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The left eye of 10 adults with healthy corneas was patched using a folded eye pad for 30\u2009min. High\u2010resolution optical coherence tomography images (which captured the limbal and central corneal regions simultaneously) were obtained before patching, immediately after eye opening and again at 1, 2, 5, 6, 9, 10, 14 and 15\u2009mins after eyelid opening. Oedema was measured from the limbus (scleral spur) to the central cornea (thinnest corneal location) along the horizontal meridian.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A greater amount of limbal oedema was noted (mean [SD] 3.84 [1.79] %) compared to the central cornea (2.48 [0.61] %;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) after 30\u2009mins of unilateral eyelid closure. Both central and limbal corneal oedema recovered rapidly following eyelid opening, with no significant differences in the rate of corneal recovery between corneal locations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.90).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Short\u2010term unilateral eyelid closure resulted in ~55% more relative oedema in the limbal region compared to the central cornea. Rapid recovery of oedema and corneal overshoot (thinning beyond the baseline corneal thickness) was observed within 1\u20132\u2009min of eyelid opening for both central and peripheral regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13380","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T03:28:52Z","timestamp":1724124532000},"page":"1524-1529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The central and peripheral corneal response to short\u2010term hypoxia"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-1248","authenticated-orcid":false,"given":"Asif","family":"Iqbal","sequence":"first","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research, Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-5196","authenticated-orcid":false,"given":"Damien","family":"Fisher","sequence":"additional","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research, Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-6592","authenticated-orcid":false,"given":"David","family":"Alonso\u2010Caneiro","sequence":"additional","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research, Queensland University of Technology  Brisbane Queensland Australia"},{"name":"School of Science, Technology and Engineering, University of Sunshine Coast  Petrie Queensland 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