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Psychophysical tasks measuring (A) contrast increment and decrement sensitivity and (B) response times to increment and decrement targets were assessed as surrogate measures of ON and OFF retinal ganglion cell function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The group with diabetes had worse foveal contrast increment and decrement thresholds (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and were slower to search for increment and decrement targets relative to controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Individuals with diabetes had a less circular foveal avascular zone (FAZ) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) but did not differ from controls in foveal vessel density and FAZ area. Functional and structural outcome measures related to the peripheral retina were also comparable between those with and without diabetes. Functional responses to increments and decrements were not significantly correlated with FAZ circularity or vessel density in individuals with diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diabetic retinal disease results in impaired performance on measures of inferred ON and OFF pathway function in addition to vascular deficits measurable with OCTA. Future longitudinal studies may determine the temporal relationship between these deficits, and whether they predict future diabetic retinopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13394","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T10:30:05Z","timestamp":1728901805000},"page":"77-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The relationship between ON\u2013OFF function and OCT structural and angiographic parameters in early diabetic retinal disease"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9656-1392","authenticated-orcid":false,"given":"Vanessa T. 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