{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T08:43:29Z","timestamp":1784450609985,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the magnitude of central, mid\u2010peripheral and peripheral stromal corneal oedema induced during short\u2010term fenestrated and non\u2010fenestrated scleral lens wear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Nine healthy participants wore a non\u2010fenestrated and a fenestrated (0.3\u2010mm diameter limbal fenestration) scleral lens (KATT\u2122, Capricornia Contact Lenses), hexafocon B material (Dk 141 \u00d7\u200910\n                      <jats:sup>\u221211<\/jats:sup>\n                      \u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      (cm)\/[(s) (cm\n                      <jats:sup>2<\/jats:sup>\n                      ) (mmHg)]) in one eye under open\u2010eye conditions for 90\u2009min on two separate days. Scleral lens thickness, fluid reservoir thickness and stromal corneal oedema were measured using high\u2010resolution optical coherence tomography. Stromal oedema was quantified across the central (0\u20132.5\u2009mm from the corneal apex), mid\u2010peripheral (\u22123.0 to \u22121.0\u2009mm from the scleral spur) and peripheral (\u22121.0 to 0\u2009mm from the scleral spur) cornea with the lens in\u00a0situ. The magnitude of oedema was corrected based on variations in fluid reservoir thickness between the lens conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant effect of lens type (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) on stromal oedema, with less oedema observed with the fenestrated (0.36\u2009\u00b1\u20090.45%) compared to the non\u2010fenestrated lenses (1.24\u2009\u00b1\u20090.27%), averaged across all corneal locations. A significant lens type by corneal location interaction was also observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05), with less oedema observed in the peripheral region for the fenestrated (\u22120.15\u2009\u00b1\u20090.98%) compared to the non\u2010fenestrated lenses (1.81\u2009\u00b1\u20090.57%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048). A fenestration location by corneal location interaction was also observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), indicating a greater reduction in oedema closer to the fenestration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Central and mid\u2010peripheral stromal oedema was similar during fenestrated and non\u2010fenestrated lens wear; however, fenestrated lenses displayed significantly less oedema in the peripheral cornea. This is most likely due to increased oxygen delivery in proximity to the fenestration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13489","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:20:09Z","timestamp":1741839609000},"page":"618-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Regional variations in corneal oedema during open\u2010eye fenestrated scleral lens wear"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-1248","authenticated-orcid":false,"given":"Asif","family":"Iqbal","sequence":"first","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-5196","authenticated-orcid":false,"given":"Damien","family":"Fisher","sequence":"additional","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-6592","authenticated-orcid":false,"given":"David","family":"Alonso\u2010Caneiro","sequence":"additional","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research Queensland University of Technology  Brisbane Queensland Australia"},{"name":"School of Science, Technology and Engineering University of Sunshine Coast  Petrie Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-5498","authenticated-orcid":false,"given":"Michael J.","family":"Collins","sequence":"additional","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5998-1320","authenticated-orcid":false,"given":"Stephen J.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research Queensland University of Technology  Brisbane Queensland 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