{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:11:56Z","timestamp":1782533516671,"version":"3.54.5"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This three\u2010dimensional study investigated how different contact lens materials affect oxygen levels in the cornea. Specifically, it measured oxygen tension, flux and consumption in the epithelium, stroma and endothelium when exposed to various contact lenses. The goal was to understand how oxygen distribution within the cornea changes based on the oxygen tension at the cornea\u2013tear interface, which is influenced by the lens's oxygen transmissibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To achieve this goal, a finite element analysis model was used that accounted for the axisymmetric properties of the cornea. A parametric analysis was conducted to examine how lens power and refractive index impacted oxygen distribution. This involved testing various contact lens materials with different powers (\u00b13 and \u00b16D) and refractive indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This three\u2010dimensional model provides new insights into the flux and concentration profiles of oxygen across the epithelium, stroma and endothelium for contact lenses having different optical powers. The key findings show that contact lens thickness and refractive index, which are related to the power, significantly impact oxygen concentration within the cornea. Notably, reduced corneal oxygen consumption occurs primarily at the epithelium, where oxygen tension decreases under both open\u2010eye and closed\u2010eye conditions. This decrease depends on the oxygen permeability of the contact lens being worn and its power.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The cornea can sustain normal metabolic processes (aerobic metabolism) if the oxygen levels at the cornea\u2013tear film interface are within approximately 60\u2013100\u2009mmHg. This holds true for all of the contact lenses tested here under open\u2010eye conditions. However, when the eyes are closed, the cornea is unable to maintain normal metabolic processes, leading to a shift towards anaerobic metabolism. Prolonged exposure to these conditions can cause corneal oedema (swelling) due to an inadequate oxygen supply.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13510","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:07:51Z","timestamp":1745035671000},"page":"1126-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A new three\u2010dimensional model to describe human corneal oxygenation during contact lenses wear"],"prefix":"10.1007","volume":"45","author":[{"given":"Jos\u00e9 M.","family":"Goz\u00e1lvez\u2010Zafrilla","sequence":"first","affiliation":[{"name":"Institute for Industrial, Radiophysical and Environmental Safety (ISIRYM), Departamento de Ingenier\u00eda Qu\u00edmica y Nuclear Universitat Polit\u00e9cnica de Valencia  Campus de Vera Valencia 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