{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:48:18Z","timestamp":1792237698365,"version":"4.4.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy of CARE spectacle lenses in slowing myopia progression among European children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a 2\u2010year randomised, parallel\u2010group, double\u2010masked, multicentre clinical trial, 234 European children aged 6\u201313\u2009years were enrolled. All participants were myopic, with a cycloplegic spherical equivalent refractive error (SE) between \u22120.75 D and \u22125.00 D, astigmatism \u22641.50 D, anisometropia \u22641.00 D and myopia progression of at least 0.50 D in the previous year. The treatment group received MyoCare spectacle lenses with cylinder annular refractive elements (CARE), the control group single\u2010vision lenses (SVL). Axial length (AL) and SE were measured at baseline, 6 and 12\u2009months. Wearability questionnaires were administered at 1\u2009week and 3\u2009months. Central and peripheral visual acuity (VA) was recorded at dispensing and after 3\u2009months. Generalised linear models estimated changes in SE and AL, adjusting for lens type, age and baseline measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12\u2009months, children wearing CARE lenses showed less myopia progression, with a difference in SE and AL progression (compared to SVL) of \u22120.21 D (CI: 0.10 to 0.32 D) and 0.14\u2009mm (CI: \u22120.17 to \u22120.10\u2009mm), respectively. Central VA did not decrease with CARE lenses. Peripheral VA decreased by 0.10 and 0.09 logMAR in the nasal and temporal zones, respectively. Analysis of fast progressors indicated that 39.7% of SVL wearing eyes progressed by \u2264\u22120.50 D\/year compared to 21.1% with CARE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). For AL, 56.0% of SVL children had an elongation \u22650.20\u2009mm compared to 21.3% with CARE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In European children, myopia progression was significantly slower with\n                      <jats:styled-content style=\"fixed-case\">CARE<\/jats:styled-content>\n                      lenses compared with\n                      <jats:styled-content style=\"fixed-case\">SVL<\/jats:styled-content>\n                      after 1\u2009year of lens wear. Further monitoring will provide a comprehensive evaluation of long\u2010term efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13517","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:29:57Z","timestamp":1745900997000},"page":"1025-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical evaluation of MyoCare in Europe (CEME) for myopia management: One\u2010year results"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-4581","authenticated-orcid":false,"given":"Cristina","family":"Alvarez\u2010Peregrina","sequence":"first","affiliation":[{"name":"Department of Optometry and Vision, Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-1789","authenticated-orcid":false,"given":"Miguel Angel","family":"Sanchez\u2010Tena","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision, Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"},{"name":"ISEC LISBOA\u2014Instituto Superior de Educa\u00e7\u00e3o e Ci\u00eancias  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-8264","authenticated-orcid":false,"given":"Cesar","family":"Villa\u2010Collar","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical and Health Sciences Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0996-5007","authenticated-orcid":false,"given":"Clara","family":"Martinez\u2010Perez","sequence":"additional","affiliation":[{"name":"ISEC LISBOA\u2014Instituto Superior de Educa\u00e7\u00e3o e Ci\u00eancias  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"de Corcuera\u2010Terrero","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision, Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-3467","authenticated-orcid":false,"given":"Nicole","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales  Sydney Australia"},{"name":"ZEISS Vision Care, Carl Zeiss Vision International GmbH  Aalen BW Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Li","sequence":"additional","affiliation":[{"name":"ZEISS Vision Care, Carl Zeiss Vision (Guangzhou) Ltd.  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