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Mydriasis was induced by instilling 0.5% tropicamide eye drops three times at 10\u2010min intervals. Thirty minutes after the final instillation, examinations were repeated using the Pentacam and Corvis ST. Measurement parameters included corneal topographic data (curvature\u2010based parameters, elevation\u2010based data, pachymetric values, integrated keratoconus indices and the Belin\/Ambr\u00f3sio total deviation value [BAD\u2010D]) and biomechanical data (dynamic corneal response parameters, Vinciguerra screening parameters, Corvis biomechanical index and tomographic\u2010biomechanical index). Violin plots were used to visualise the distribution patterns of the measured parameters. Differences between pre\u2010 and post\u2010mydriatic measurements were analysed using paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following mydriasis, the Pentacam analysis revealed statistically significant decreases in front mean keratometry, front maximum keratometry, back mean keratometry, index of surface variance, central keratoconus index and BAD\u2010D (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In contrast, central corneal thickness, apex corneal thickness, thinnest corneal thickness and minimum sagittal curvature showed significant increases. Corvis ST biomechanical analysis demonstrated significant reductions in the time from the start to the second applanation, deformation amplitude of the corneal apex at the highest concavity and Corvis biomechanical index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mydriasis produced significant alterations in corneal topographic and biomechanical parameters in participants with KC. Although these changes do not affect the diagnosis of the condition, clinicians should be aware of them and adjust their treatment planning accordingly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.70011","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T11:59:56Z","timestamp":1758023996000},"page":"1761-1772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in corneal topography and corneal biomechanics in keratoconus after mydriasis"],"prefix":"10.1007","volume":"45","author":[{"given":"Jinjin","family":"Yu","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital, Fudan\u00a0University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Research Centre of Ophthalmology and Optometry  Shanghai China"},{"name":"Ningbo No. 2 Hospital  Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Huang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital, Fudan\u00a0University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Research Centre of Ophthalmology and Optometry  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ning","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital, Fudan\u00a0University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Research Centre of Ophthalmology and Optometry  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital, Fudan\u00a0University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Research Centre of Ophthalmology and Optometry  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-5170","authenticated-orcid":false,"given":"Chak Seng","family":"Lei","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital, Fudan\u00a0University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Research Centre of Ophthalmology and Optometry  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxian","family":"Pan","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital, Fudan\u00a0University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Research Centre of Ophthalmology and Optometry  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxuan","family":"Xiahou","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye &amp; ENT Hospital, Fudan\u00a0University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Research Centre of Ophthalmology and Optometry  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Savini","sequence":"additional","affiliation":[{"name":"I.R.C.C.S. 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