{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:41:16Z","timestamp":1791124876410,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy and safety of 0.01% atropine eye drops in preventing myopia in children with pre\u2010myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomised controlled trial (ChiCTR2200055482), children aged 5\u201312\u2009years with cycloplegic spherical equivalent (SE) between +0.75D and \u22120.50D were randomised 1:1 to receive either 0.01% atropine (once nightly) or placebo (once nightly). The primary endpoint was the change in SE after 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010four subjects (48.4% female) completed the 12\u2010month follow\u2010up (32 per group, mean age, 7.47\u2009\u00b1\u20091.72 vs. 7.84\u2009\u00b1\u20091.32\u2009years). After 12\u2009months, the change in SE was significantly smaller in the 0.01% atropine group than in the placebo group (\u22120.23\u2009\u00b1\u20090.50D vs. \u22120.49\u2009\u00b1\u20090.42D;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), representing a 53% reduction in myopia progression. No significant intergroup difference was observed in axial length (AL) change (+0.26\u2009\u00b1\u20090.16\u2009mm vs. +0.32\u2009\u00b1\u20090.15\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.13), corresponding to a 19% reduction in AL elongation. The 0.01% atropine group exhibited significantly larger pupil diameters at all time points (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while safety parameters (e.g., amplitude of accommodation, tear film stability, intraocular pressure) remained comparable between the groups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In 5\u2010 to 12\u2010year\u2010old pre\u2010myopic children, nightly administration of 0.01% atropine eye drops for 1\u2009year was found to delay myopic shift compared with placebo, and no persistent adverse events were observed. Additionally, the atropine group exhibited less axial elongation than the control group, though this difference was not statistically significant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.70018","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:48:19Z","timestamp":1757688499000},"page":"1924-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["0.01% Atropine for Myopia Prevention in Pre\u2010myopia (\n                    <scp>AMPP<\/scp>\n                    study)"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-7620","authenticated-orcid":false,"given":"Meinan","family":"He","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry Tianjin Medical University 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and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-7016","authenticated-orcid":false,"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin 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