{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:08:58Z","timestamp":1791842938125,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the association between summed relative corneal refractive power (sRCRP) and age\u2010adjusted axial length growth (aALG) in children undergoing orthokeratology (OK), and to determine whether this relationship is moderated by the axial length to corneal curvature (AL\/K) ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 318 eyes of children (8\u201313\u2009years of age) treated with OK lens for 1\u2009year. Corneal curvature (CC) was quantified using mean keratometry (K) values, and the AL\/K ratio was used to represent baseline ocular structure. Axial length growth (ALG) over 1\u2009year was adjusted for age (aALG). sRCRP was derived from 1\u2010year axial maps within the central 4\u2009mm. Associations between sRCRP and aALG were assessed by multiple linear regression, with moderation assessed via interaction terms, simple slopes analysis and the Johnson\u2013Neyman technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean sRCRP was 19.39\u2009\u00b1\u200910.29 D\u00b7mm\n                      <jats:sup>2<\/jats:sup>\n                      and the mean aALG was \u22120.07\u2009\u00b1\u20090.21\u2009mm after 1\u2009year. Multivariate regression showed that sRCRP (\u03b2\u2009=\u2009\u22120.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), baseline AL (\u03b2\u2009=\u2009\u22120.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and spherical equivalent refraction (\u03b2\u2009=\u2009\u22120.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) were significant predictors of aALG. A significant interaction between sRCRP and AL\/K ratio (\u03b2\u2009=\u20090.10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) indicated that the effect of sRCRP on aALG varied with baseline ocular structure. Johnson\u2013Neyman analysis revealed that sRCRP was significantly associated with reduced aALG only when the AL\/K ratio was below 0.61.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The AL\/K ratio moderates the relationship between sRCRP and myopia control efficacy in OK lens treatment. sRCRP is predictive of treatment outcome primarily in eyes with lower AL\/K ratios, supporting the role of biometric profiling in guiding individual OK lens strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.70036","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:35:02Z","timestamp":1761381302000},"page":"1981-1988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Axial length to corneal curvature ratio moderates the effect of corneal reshaping on axial growth in orthokeratology"],"prefix":"10.1007","volume":"45","author":[{"given":"Liuyun","family":"Chong","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin Medical University Optometry Technology Co., Ltd  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Bi","sequence":"additional","affiliation":[{"name":"College of Optometry, Nova Southeastern University  Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Lin","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianpu","family":"Gu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Du","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Optometry, Nova Southeastern University  Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-0355","authenticated-orcid":false,"given":"Ruihua","family":"Wei","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2024.102167"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2024.102122"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2024.102251"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2022-321272"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010021\u201002123\u2010x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13070"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010022\u201002693\u20104"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010022\u201002396\u2010w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12996"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13208"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2020.1820528"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.7.6.17"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.686932"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2022.101749"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2024.04.16"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.02.025"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-0484(01)80008-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12812"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000001119"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13276"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12817"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.12.8.14"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13159"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243416"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13347"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40662\u2010023\u201000358\u2010x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13213"},{"key":"e_1_2_11_29_1","first-page":"1110","article-title":"Myopia 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