{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:02:45Z","timestamp":1780056165457,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Developmental abnormalities of the appendicular skeleton are among the most common and easily identified birth defects. The aim of this report was to describe the phenotypic characterization of several patients with thrombocytopenia\u2010absent radius (<jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content>) syndrome and the orthopaedic interventions performed on them. <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> syndrome is inherited in an autosomal recessive manner and results from compound heterozygosity of <jats:italic><jats:styled-content style=\"fixed-case\">RBM8A<\/jats:styled-content><\/jats:italic> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Reconstructions were designed and performed in five patients with <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> syndrome, mainly comprising orthopaedic interventions to correct their upper limb defects. Additional lower limb deformities (severe internal rotation of the tibiae) was been encountered in one patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The affected patients\u2019 wrists were re\u2010aligned and stabilized and the musculotendinous forces around the wrist rebalanced to reverse the ulnar forearm bow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> syndrome who receive optimal treatment can expect to return to most activities of daily living with some limitation of wrist extension and ulnar deviation and, of course, with a reduced total active range of digital motion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12157","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T02:47:38Z","timestamp":1424746058000},"page":"50-56","source":"Crossref","is-referenced-by-count":13,"title":["Reconstruction of Limb Deformities in Patients with Thrombocytopenia\u2010absent Radius Syndrome"],"prefix":"10.1111","volume":"7","author":[{"given":"Ali","family":"Al Kaissi","sequence":"first","affiliation":[{"name":"Ludwig Boltzmann Institute of Osteology Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling  Vienna Austria"},{"name":"First Medical Department Hanusch Hospital  Vienna Austria"},{"name":"Paediatric Department Orthopaedic Hospital of Speising  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Girsch","sequence":"additional","affiliation":[{"name":"Paediatric Department Orthopaedic Hospital of Speising  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Kenis","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery Neuro\u2010orthopaedics and Systemic Disorders Pediatric Orthopaedic Institute n.a. H. Turner  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeniy","family":"Melchenko","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery Neuro\u2010orthopaedics and Systemic Disorders Pediatric Orthopaedic Institute n.a. H. Turner  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher","family":"Ben Ghachem","sequence":"additional","affiliation":[{"name":"Paediatric Orthopaedic Surgery Children Hospital  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Pospischill","sequence":"additional","affiliation":[{"name":"Paediatric Department Orthopaedic Hospital of Speising  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Klaushofer","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute of Osteology Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling  Vienna Austria"},{"name":"First Medical Department Hanusch Hospital  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Grill","sequence":"additional","affiliation":[{"name":"Paediatric Department Orthopaedic Hospital of Speising  Vienna 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