{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T23:57:02Z","timestamp":1772063822674,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Objective<\/jats:title>Advanced oxidation protein products (AOPPs<\/jats:styled-content>), a marker of oxidative stress, are prevalent in many kinds of disorders. Osteoarthritis (OA<\/jats:styled-content>), mainly resulting from the regression of cartilage, chronic inflammation of the synovium and the subchondral bone remodeling. Although the inflammatory response of AOPPs<\/jats:styled-content> on fibroblast\u2010like synoviocytes (FLSs<\/jats:styled-content>) were reported, the effect of AOPPs<\/jats:styled-content> on cartilage and synovial in vivo remains unclear. Therefore, our study aims to investigate whether AOPPs<\/jats:styled-content> have an effect on the articular cartilage and synovial in a rabbit model of OA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>OA<\/jats:styled-content> model were created by anterior cruciate ligament transection and medial meniscus resection (ACLT<\/jats:styled-content> + MMx<\/jats:styled-content>). Forty\u2010eight male N<\/jats:styled-content>ew Z<\/jats:styled-content>ealand rabbits were randomly divided into 3 groups: sham\u2010operated group, AOPPs\/ACLT<\/jats:styled-content> + MMx<\/jats:styled-content> group, and phosphate buffered saline (PBS<\/jats:styled-content>)\/ACLT<\/jats:styled-content> + MMx<\/jats:styled-content> group. In sham\u2010operated group, the anterior cruciate ligament was just exposed without transection, and then the incision was sutured. Then intra\u2010articular injection of AOPPs<\/jats:styled-content> or PBS was performed in the other two groups. Through four weeks and eight weeks of treatment, rabbits in each group were sacrificed. Both hind legs were removed. I<\/jats:styled-content>ndia ink staining and Safranin O<\/jats:styled-content> and fast green staining were used to evaluate the macroscopic and microscopic cartilage morphology. The protein expression of matrix metalloproteinases (MMP<\/jats:styled-content>)\u20103, MMP<\/jats:styled-content>\u201013 in synovium was measured by W<\/jats:styled-content>estern blot.<\/jats:p><\/jats:sec>Result<\/jats:title>The I<\/jats:styled-content>ndia ink score and Mankin score of AOPPs\/ACLT<\/jats:styled-content> + MMx<\/jats:styled-content> group were both higher than the other two groups at the two time points. W<\/jats:styled-content>estern blot have revealed that intra\u2010articular injection of AOPPs<\/jats:styled-content> upregulated the protein expression of MMP<\/jats:styled-content>\u20103 and MMP<\/jats:styled-content>\u201013 in synovium.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>AOPPs<\/jats:styled-content> participated in the occurrence and development of OA<\/jats:styled-content> by upregulating the protein expression of MMP<\/jats:styled-content>\u20103 and MMP<\/jats:styled-content>\u201013 in synovium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12179","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T06:44:26Z","timestamp":1433141066000},"page":"161-167","source":"Crossref","is-referenced-by-count":27,"title":["Effect of Advanced Oxidation Protein Products on Articular Cartilage and Synovium in a Rabbit Osteoarthritis Model"],"prefix":"10.1111","volume":"7","author":[{"given":"Hui","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery Nanfang Hospital Southern Medical University Guangzhou GuangDong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010bin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Nanfang Hospital Southern Medical University Guangzhou GuangDong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao\u2010ming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Nanfang Hospital Southern Medical University Guangzhou GuangDong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo\u2010ting","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Nanfang Hospital Southern Medical University Guangzhou GuangDong 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