{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:32:33Z","timestamp":1772022753713,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>The objective of this systematic review and meta\u2010analysis was to evaluate the efficacy and safety of i.v. tranexamic acid (<jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>) in simultaneous bilateral total knee arthroplasty (<jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>). Potentially relevant published reports were identified from the following electronic databases: Medline, PubMed, Embase, ScienceDirect and Cochrane Library. RevMan v5.3was used to pool data. Two randomized controlled trials and four case\u2010control studies met the inclusion criteria. The current meta\u2010analysis identified significant differences between <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content> group and control groups in terms of postoperative hemoglobin concentration (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> &lt; 0.01), drainage volume (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> &lt; 0.01), transfusion rate (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> &lt; 0.01) and units transfused (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> = 0.006). There were no significant differences in length of stay (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> = 0.66), operation time (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> = 0.81) or and incidence of adverse effects such as infection (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> = 0.42), deep venous thrombosis (<jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> = 0.88) and pulmonary embolism (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> = 0.11). Our results show that i.v. administration of <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content> in simultaneous bilateral <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content> reduces postoperative drops in hemoglobin concentration, drainage volume, and transfusion requirements and does not prolong length of stay or operation time. Moreover, no adverse effects, such as infection, <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PE,<\/jats:styled-content> were associated with <jats:styled-content style=\"fixed-case\">TXA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/os.12256","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T16:25:51Z","timestamp":1473870351000},"page":"285-293","source":"Crossref","is-referenced-by-count":24,"title":["Efficiency and Safety of Intravenous Tranexamic Acid in Simultaneous Bilateral Total Knee Arthroplasty: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1111","volume":"8","author":[{"given":"Xuan","family":"Jiang","sequence":"first","affiliation":[{"name":"Graduate School of General Hospital Tianjin Medical University  Tianjin China"},{"name":"Department of Orthopaedics Tianjin Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010long","family":"Ma","sequence":"additional","affiliation":[{"name":"Graduate School of General Hospital Tianjin Medical University  Tianjin China"},{"name":"Department of Orthopaedics Tianjin Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010xiong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Tianjin Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,14]]},"container-title":["Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fos.12256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fos.12256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.12256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T03:42:01Z","timestamp":1695958921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/os.12256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/os.12256"],"URL":"https:\/\/doi.org\/10.1111\/os.12256","archive":["Portico"],"relation":{},"ISSN":["1757-7853","1757-7861"],"issn-type":[{"value":"1757-7853","type":"print"},{"value":"1757-7861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}