{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:19:14Z","timestamp":1770999554086,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This randomized, double\u2010blind, placebo\u2010controlled study assessed the necessity of early intervention, safety and efficacy of intravenous zoledronic acid 5 mg\/year in East China women with newly diagnosed osteoporosis at high risk of fracture during a 24\u2010month treatment period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects (57 [52\u201362] years old) were randomized 3:2 to zoledronic acid versus placebo (randomized at baseline, zoledronic acid [175 cases], placebo\u2010zoledronic acid [110 cases]). The bone mineral density of the lumbar spine and total hip was measured every 6 months with the use of dual\u2010energy X\u2010ray absorptiometry. Serum procollagen <jats:styled-content style=\"fixed-case\">I N<\/jats:styled-content>\u2010terminal pro\u2010peptide (<jats:styled-content style=\"fixed-case\">PINP<\/jats:styled-content>) and serum C\u2010telopeptide of type I collagen (<jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>) levels were measured every 6 months. The primary end point was the rate of change in the bone mineral density at the posteroanterior spine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For subjects with measurements at 24 months, zoledronic acid significantly increased bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) at the lumbar spine (mean percent change \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, zoledronic acid 5.390% \u00b1 0.854% versus placebo\u2010zoledronic acid \u22121.038% \u00b1 0.599%), the total hip (zoledronic acid 1.900% \u00b1 0.262% versus placebo\u2013zoledronic acid \u22121.631% \u00b1 0.649%). Serum procollagen <jats:styled-content style=\"fixed-case\">I N<\/jats:styled-content>\u2010terminal pro\u2010peptide (<jats:styled-content style=\"fixed-case\">PINP<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content> decreased rapidly with zoledronic acid 5 mg treatment (<jats:italic>P<\/jats:italic> &lt; 0.001 versus placebo at 6 month and 24 months) and changed from baseline in the zoledronic acid 5 mg and placebo\u2013zoledronic acid 5 mg at 6 months by a mean of \u221266.348% and \u221275.375%, respectively (<jats:italic>P<\/jats:italic> &lt; 0.001), and at 24 months by \u221249.950% and \u221252.325%, respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). No cases of serious adverse events were observed in two groups. Headache, pyrexia and myalgia occurred more commonly within the first 3 days after infusion with zoledronic acid 5 mg than with placebo (13.7% versus 2.1%, <jats:italic>P<\/jats:italic> = 0.0018; 28.0% versus 3.2%, <jats:italic>P<\/jats:italic> &lt; 0.001; 21.7% versus 4.2%, <jats:italic>P<\/jats:italic> &lt; 0.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data show that early application of zoledronic acid 5 mg\/year was well stimulated and tolerated for bone mass in newly diagnosed east china subjects with osteoporosis in a 24\u2010month treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12307","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T11:22:59Z","timestamp":1489058579000},"page":"103-109","source":"Crossref","is-referenced-by-count":22,"title":["Intravenous Zoledronic Acid 5 mg on Bone Turnover Markers and Bone Mineral Density in East China Subjects with Newly Diagnosed Osteoporosis: A 24\u2010month Clinical Study"],"prefix":"10.1111","volume":"9","author":[{"given":"Bo\u2010cheng","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Osteology Second Clinical Medical College, Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Department of Osteology The Second Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Osteology Second Clinical Medical College, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Osteology Second Clinical Medical College, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Osteology Second Clinical Medical College, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling\u2010cheng","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Osteology Second Clinical Medical College, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010liang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Osteology Second Clinical Medical College, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Diagnostics of Traditional Chinese Medicine College of Basic Medical Science, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Osteology The Second Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou 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