{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:39:08Z","timestamp":1778395148329,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T00:00:00Z","timestamp":1496966400000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81472140"],"award-info":[{"award-number":["81472140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology fund of Tianjin Municipal Bureau of Health","award":["15KG124"],"award-info":[{"award-number":["15KG124"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical outcomes and complications of segmental prosthetic reconstruction for pathological diaphyseal femoral fractures secondary to metastatic tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2011 and 2015, we retrospectively evaluated 16 patients (6 men and 10 women; 64.5 \u00b1 11.4 years old at diagnosis) who underwent prosthetic reconstruction after segmental resection of diaphyseal femoral fractures due to metastatic lesions. Visual analog scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>), functional outcomes, implant\u2010related complications, and Mean postoperative Musculoskeletal Tumor Society (<jats:styled-content style=\"fixed-case\">MSTS<\/jats:styled-content>) score for each patient were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean length of bone defect was 10.2 \u00b1 2.6 cm (range, 8\u201316 cm); follow\u2010up was 9 \u00b1 6.8 months (range, 2\u201325 months) for all patients, and 24 months (23 and 25 months) for the 2 patients still alive. At final follow\u2010up, 14 patients were dead, indicating a mean survival of 6.9 \u00b1 3.6 months (range, 2\u201314 months). Mean preoperative <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score was 8.5 \u00b1 1.0, which decreased to 2.5 \u00b1 1.3 at day 2 postoperatively, indicating significant pain relief (<jats:italic>P<\/jats:italic> &lt; 0.05). The <jats:styled-content style=\"fixed-case\">MSTS<\/jats:styled-content> score for lower extremities was 84.6% (range, 73%\u201390%). The range of motion and function of adjacent joints was within the normal limits in all cases. Three patients (33%) developed complications, including aseptic loosening because of disease progression (1), infection (1), and peri\u2010prosthesis fracture (1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings demonstrated that this approach greatly relieves pain, and yields satisfactory functional outcomes with fewer complications in patients with pathological femoral fractures secondary to metastatic tumors; however, survival was not significantly improved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12327","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T13:25:06Z","timestamp":1497014706000},"page":"221-228","source":"Crossref","is-referenced-by-count":21,"title":["Outcomes of Intercalary Prosthetic Reconstruction for Pathological Diaphyseal Femoral Fractures Secondary to Metastatic Tumors"],"prefix":"10.1111","volume":"9","author":[{"given":"Hong\u2010chao","family":"Huang","sequence":"first","affiliation":[{"name":"The Graduate School Tianjin Medical University  Tianjin China"},{"name":"Department of Bone Oncology Tianjin Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010cheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Bone Oncology Tianjin Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deng\u2010xing","family":"Lun","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Weifang People's Hospital  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Tianjin Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Graduate School Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong\u2010gang","family":"Yang","sequence":"additional","affiliation":[{"name":"The Graduate School Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010long","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Tianjin Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1965.3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-4064-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658080-00002"},{"key":"e_1_2_6_5_1","first-page":"231","article-title":"Metastatic diaphyseal fractures of the shaft of the humerus. 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