{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:38:55Z","timestamp":1783600735863,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>It has been reported that acute\u2010phase reactions (<jats:styled-content style=\"fixed-case\">APR<\/jats:styled-content>) after infusion of 5\u2009mg zoledronic acid for the first time is common. This study surveyed the incidence and characteristics of <jats:styled-content style=\"fixed-case\">APR<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese postmenopausal women receiving 5\u2009mg zoledronic acid intravenously for osteoporosis and to evaluate the efficacy of non\u2010steroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>) in preventing or alleviating <jats:styled-content style=\"fixed-case\">APR<\/jats:styled-content> following the first 5\u2009mg zoledronic acid infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 2601 patients with an average age of 68.14 \u00b1 9.89\u2009years and a mean body mass index of 22.90 \u00b1 3.24\u2009kg\/m<jats:sup>2<\/jats:sup> from 62 centers in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina were treated with 5\u2009mg zoledronic acid intravenously for the first time. The incidence of fever and pain were observed in these patients, and the time of fever or pain onset and duration, and the intensity of fever and grade of pain were also recorded. The dosage, duration, and efficacy of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> and safety outcomes were also documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the study, 18 patients are eliminated due to incomplete records of temperature. The incidence of fever was 28.65% (740\/2583) within 7\u2009days following zoledronic acid infusion; 98.34% (727\/740) occurred at 1.03 \u00b1 0.66\u2009days after infusion and lasted 1.72 \u00b1 0.93\u2009days. A total of 456 (17.53%) patients had newly onset pain (312 of 1187, 26.28%) or experienced pain aggravation (144 of 1414, 10.18%), which mostly occurred within 3\u2009days after zoledronic acid infusion. A total of 1246 (47.6%) patients had received <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> for a median time of 2.63 \u00b1 2.45\u2009days. Using <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> for at least 2\u2009days could decrease body temperature by 0.54 \u00b1 0.86\u00b0C, increase the percentage of pain\u2010free patients by 6.17%, and reduce the percentage of patients with moderate to severe pain by 8.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with Western populations, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients had a higher rate of fever and pain after their first zoledronic acid infusion. These symptoms were often mild to moderate in intensity and transient in duration. <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> could effectively reduce the incidence and severity of such <jats:styled-content style=\"fixed-case\">APR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12338","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T15:05:24Z","timestamp":1506697524000},"page":"284-289","source":"Crossref","is-referenced-by-count":39,"title":["Multicenter Study on Observation of Acute\u2010phase Responses After Infusion of <scp>Z<\/scp>oledronic Acid 5\u2009mg in <scp>C<\/scp>hinese Women with Postmenopausal Osteoporosis"],"prefix":"10.1111","volume":"9","author":[{"given":"Yue","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Cheng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, China\u2010Japan Union Hospital Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics the First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University  Guangzhou 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Affiliated Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010xing","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, West China Hospital Sichuan University  Chengdu 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