{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:39:52Z","timestamp":1792190392601,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>There are several types of metaphyseal chondrodysplasia and various clinical types have been differentiated. The Schmid type of metaphyseal chondrodysplasia is the most common. Diffuse metaphyseal flaring, irregularity, and growth plate widening, which are most severe in the knees, are the most striking radiological features of this disease. The Schmid type of metaphyseal dysostosis is characterized by failure of normal mineralization of the zone of provisional calcification, leading to widened physes and enlarged knobby metaphyses, effectively causing shortening of the tubular bones, splaying of the metaphyses, coxa vara, and bow legs. Orthopaedic interventions were primarily performed on the lower extremities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve children (seven girls and five boys) aged 7\u201310\u2009years were enrolled in this study. Moderate short stature was a uniform feature associated with predominant involvement of the proximal femora and bow legs resulted in the development of angular deformities. A waddling gait was a consequence of coxa vara in eight children. Valgus osteotomy of the proximal femur was planned after physeal closure for the group of children with coxa vara. Hemiepiphysiodesis was performed to re\u2010align the genu varum in three children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Other forms of metaphyseal dysostosis were ruled based on full clinical and radiographic phenotypes, with confirmation through molecular pathology. Mutations in the <jats:italic>COL10A1<\/jats:italic> gene located on chromosome 6q21\u2010q22.3 were confirmed. Re\u2010alignment was accomplished in our group of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The most striking clinical features of Schmid metaphyseal chondrodysplasia which appear within the first 2\u20133\u2009years of life are: moderate short limbs and short stature, a waddling gait, and increasing shortness of stature with age. The Schmid type of metaphyseal chondrodysplasia is a disorder that arises from defective type X collagen, which is typically found in the hypertrophic zone of the physes. Moderate short stature and a waddling gait associated with pain are the most common clinical presentations. Osteotomies to correct bow legs are sometimes combined with lengthening procedures. Recurrence of the deformities with growth is not uncommon; therefore, hemiepiphysiodesis or stapling might be indicated in some cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12382","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T02:01:38Z","timestamp":1532052098000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Schmid's Type of Metaphyseal Chondrodysplasia: Diagnosis and Management"],"prefix":"10.1111","volume":"10","author":[{"given":"Ali","family":"Al Kaissi","sequence":"first","affiliation":[{"name":"First Medical Department, Hanusch Hospital Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling  Vienna Austria"},{"name":"Paediatric Department Orthopaedic Hospital of Speising  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher B","family":"Ghachem","sequence":"additional","affiliation":[{"name":"Paediatric Orthopaedic Surgery Department Children Hospital  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesseb M","family":"Nabil","sequence":"additional","affiliation":[{"name":"Paediatric Orthopaedic Surgery Department Children Hospital  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Kenis","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Neuroorthopaedics and Systemic Disorders Pediatric Orthopedic Institute n.a. H. Turner  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Melchenko","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Neuroorthopaedics and Systemic Disorders Pediatric Orthopedic Institute n.a. H. Turner  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekatrina","family":"Morenko","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Neuroorthopaedics and Systemic Disorders Pediatric Orthopedic Institute n.a. H. Turner  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Grill","sequence":"additional","affiliation":[{"name":"Paediatric Department Orthopaedic Hospital of Speising  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Ganger","sequence":"additional","affiliation":[{"name":"Paediatric Department Orthopaedic Hospital of Speising  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne G","family":"Kircher","sequence":"additional","affiliation":[{"name":"Institute of Medical Chemistry Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"393","article-title":"Beitrag zur Dysostosis enchondralis metaphysarea","volume":"97","author":"Schmid F","year":"1949","journal-title":"Monats Kinderheilkd"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30433"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00973227"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/83.4.665"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470000181"},{"key":"e_1_2_6_7_1","first-page":"621","article-title":"Achondroplasia versus pseudoachondroplasia","volume":"1","author":"Rubin P","year":"1963","journal-title":"Clin N Am"},{"key":"e_1_2_6_8_1","volume-title":"Atlas of Skeletal Dysplasia","author":"Wynne\u2010Davies R","year":"1985"},{"key":"e_1_2_6_9_1","first-page":"253","article-title":"Uber atypische Chondrodystrophie (Achondroplasie) und uber eine noch nicht beschriebene angeborene Wachstumsstorung des Knochensystems: Metaphysaere Dysostosis","volume":"61","author":"Jansen M","year":"1934","journal-title":"Zeitschr Orthop Chir"},{"key":"e_1_2_6_10_1","first-page":"285","article-title":"Dwarfism in the Amish. 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