{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:57:34Z","timestamp":1780351054847,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572629 and 81772855"],"award-info":[{"award-number":["81572629 and 81772855"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>A retrospective study was designed to evaluate the effectiveness of CT\u2010guided core needle biopsy in diagnosing spinal lesions through comparison with C\u2010arm guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From April 2013 to July 2017, a total of 188 patients, who suffered from spinal lesions or had malignant tumor history with a new spinal fracture, were included in this study. There were 96 men and 92 women, with an average of 57.1\u2009years. A total of 238 core needle biopsies were performed. A total of 140 core needle biopsies were carried out under C\u2010arm guidance in 102\u2009patients (group\u20091); 98 core needle biopsies were carried out under CT guidance in 86 patients (group 2); 108 core needle biopsies were performed in thoracic vertebrae, 116 were in lumbar vertebrae, and 14 were in sacral vertebrae. Seventy\u2010eight patients accepted surgical treatment after biopsies. For these patients, the histological pathologies of the biopsy and surgery were compared to evaluate the accuracy of the biopsy. For the other 110 patients who did not receive surgical treatment, the treatment response and the clinical course were used to evaluate the accuracy of the biopsy. The success rate, the diagnostic accuracy rate, the true positive\/negative rate, and complications of the two groups were calculated and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in sex, age, and lesion sites between the C\u2010arm guidance group (group 1) and the CT guidance group (group 2). There were no complications in the two groups. Pathological diagnoses were established in 232 of 238 biopsies. They revealed that 52 were primary malignant tumors, 12 were benign tumors, 70 were metastatic tumors, 4 were tuberculosis, and 94 were classified as \u201cother.\u201d The success rate of group 2 was higher than that of group 1, but it was not statistically significant (95.7% <jats:italic>vs<\/jats:italic> 100%; <jats:italic>P<\/jats:italic>\u2009=\u20090.098). According to the final diagnosis, the diagnostic accuracy rates were calculated and compared. There was no significant difference between the two groups (95.5% <jats:italic>vs<\/jats:italic> 96.9%; <jats:italic>P<\/jats:italic>\u2009=\u20090.835). The kappa coefficient was used to analyze the concordance between the histological pathologies of the biopsy and the final diagnosis in the two groups. The kappa values of the two group were 0.909 and 0.939, respectively. The results showed good consistency in both groups, but seemed better for group 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CT\u2010guided core needle biopsy is a relatively safe and effective procedure for diagnosing spinal lesions with a high diagnostic accuracy rate and few complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12418","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T02:05:35Z","timestamp":1550196335000},"page":"60-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Value of CT\u2010guided Core Needle Biopsy in Diagnosing Spinal Lesions: A Comparison Study"],"prefix":"10.1111","volume":"11","author":[{"given":"Yun","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Shanghai Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou\u2010lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u2010nan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010gang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shanghai Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Zhongshan Hospital Fudan University  Shanghai 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