{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:58:25Z","timestamp":1792511905920,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573754"],"award-info":[{"award-number":["81573754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To observe the effect of zoledronic acid on the reduction of acute bone loss and fracture rate in elderly postoperative patients with intertrochanteric fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From August 2012 to January 2015, a total of 482 patients with senile osteoporotic femoral intertrochanteric fracture, who accepted proximal femoral intramedullary fixation under anesthesia were analysed. The patients were divided into two groups. Treatment group (353 cases) were treated with 100\u2009mL\/5\u2009mg of zoledronic acid injection in 1 week after operation, as well as orally taken 600\u2009mg\/d of calcium carbonate and active vitamin D3 400 IU\/d. Control group (129 cases) were given the same dose of calcium carbonate and active vitamin D3 orally. Efficacy evaluation were conducted during different periods of medication<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with pre\u2010medication, indexes of bone metabolism (TARP\u20105b, CTX) in the treatment group were brought down, especially significantly statistically different after 12 months of medication. The treatment group performed superior to control group in alleviating the pain of back and posture changing (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), improving bone density (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), depressing re\u2010fracture rate (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) after 24 months of medication. In addition, BP, PF and MH dimension scores were demonstrated with statistical significance (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The application of zoledronic acidin elderly postoperative patients with intertrochanteric fracture can not only relieve acute bone loss, reduce the incidence rate of re\u2010fracture, alleviate osteoporosis pain and the pain from osteoporotic fracture, but also improve bone metabolism and quality of life, which may offer an acceptable clinical opinion<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12460","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T21:31:28Z","timestamp":1557178288000},"page":"380-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Study on Zoledronic Acid Reducing Acute Bone Loss and Fracture Rates in Elderly Postoperative Patients with Intertrochanteric Fractures"],"prefix":"10.1111","volume":"11","author":[{"given":"Zhong","family":"Liu","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010wen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Diagnostics of Traditional Chinese Medicine, College of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010fan","family":"Mao","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-3174","authenticated-orcid":false,"given":"Kang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Osteology The Second Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010cheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Osteology The Second Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian\u2010guo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Osteology The Second Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Osteology The Second Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-018-0503-z"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118178"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312116671725"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2505-z"},{"key":"e_1_2_5_6_1","first-page":"10","article-title":"A multi\u2010factorial analysis of bone morphology and fracture strength of rat femur in response to ovariectomy","volume":"13","author":"Rocabado JMR","year":"2018","journal-title":"J Orthop Surg 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