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However, it is quite difficult to transform their discovery into practical use, because the viability of the studied material might require examination of all aspects of properties. In addition, for a material to become a product, a complete procedure involving a declaration, registration, and approval is necessary. This article introduces the technical indices that the investigators and reporters should provide in their declaration and registration data to meet the relevant standards in China. The indices include physical and chemical properties, biocompatibility, biosecurity, pre\u2010clinical animal model tests, sterilization and disinfection, product duration, and packaging. Full consideration of all possible indices is crucial to realize the transformation from a designed product to a commercial medical device, which requires effective interaction between clinicians and engineers.<\/jats:p>","DOI":"10.1111\/os.12499","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T13:03:17Z","timestamp":1567774997000},"page":"720-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pre\u2010Registration Assessment of Bone\u2010Filling Products"],"prefix":"10.1111","volume":"11","author":[{"given":"Shuo","family":"Pan","sequence":"first","affiliation":[{"name":"Center for Medical Device Evaluation NMPA  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-2262","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Medical Device Evaluation NMPA  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Min","sequence":"additional","affiliation":[{"name":"Center for Medical Device Evaluation NMPA  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Medical Device Evaluation NMPA  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao","family":"Zhai","sequence":"additional","affiliation":[{"name":"Center for Medical Device Evaluation NMPA  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010heng","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Medical Device Evaluation NMPA  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1757-7861.2012.00189.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181928077"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.04.020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31269"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328215577892"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20140924-58"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.04.039"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.07.048"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/s19091958"},{"key":"e_1_2_6_11_1","first-page":"691","article-title":"Experimental research of antibacterial property and release characteristics of Titania and Ag containing nano\u2010hydroxyapatite\/polyamide 66 composite bone filling material in vitro","volume":"24","author":"Lu M","year":"2010","journal-title":"Zhongguo Xiufu Chongjian Waike Zazhi"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328212462258"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2019.04.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.05.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.03.100"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.02.012"},{"key":"e_1_2_6_17_1","unstructured":"MoseleyJP CarrollME McCanlessJD. 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