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Historically, opioids have been widely used for perioperative pain management of TKA. However, opioids are associated with undesirable adverse effects, such as nausea, respiratory depression, and retention of urine, which limit their application in daily clinical practice. The aim of this review was to discuss the current postoperative pain management regimens for TKA. Our review of the literature demonstrated that multimodal analgesia is considered the optimal regimen for perioperative pain management of TKA and improves clinical outcomes and patient satisfaction, through a combination of several types of medications and delivery routes, including preemptive analgesia, neuraxial anesthesia, peripheral nerve blockade, patient\u2010controlled analgesia and local infiltration analgesia, and oral opioid\/nonopioid medications. Multimodal analgesia provides superior pain relief, promotes recovery of the knee, and reduces opioid consumption and related adverse effects in patients undergoing TKA.<\/jats:p>","DOI":"10.1111\/os.12535","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T20:57:43Z","timestamp":1572382663000},"page":"755-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":312,"title":["Postoperative Pain Management in Total Knee Arthroplasty"],"prefix":"10.1111","volume":"11","author":[{"given":"Jing\u2010wen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Yueyang Second People's Hospital  Yueyang China"},{"name":"Department of Orthopaedic Surgery Yueyang Hospital Affiliated to Hunan Normal University  Yueyang 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