{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:24:13Z","timestamp":1775024653660,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this meta\u2010analysis was to systematically evaluate the efficacy of augmentative plating (AP) and exchange nailing (EN) in the treatment of nonunion of femoral shaft fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For the present meta\u2010analysis, PubMed, EMBASE, and the Cochrane Library were searched to identify relevant articles up to April 2019. Two investigators independently evaluated the quality of original publications following the guidelines proposed by the Cochrane Handbook. Data were extracted from the studies and analyzed using Review Manager 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five studies were included in this meta\u2010analysis, with a total of 506 patients. There were 232 patients in the AP group and 276 patients in the EN group. The AP group was associated with higher union rate (<jats:italic>OR<\/jats:italic>, 11.66; 95% <jats:italic>CI<\/jats:italic>, 4.31\u201331.50; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), shorter union time (<jats:italic>SMD<\/jats:italic>, \u22121.10; 95% <jats:italic>CI<\/jats:italic>, \u22122.09 to \u22120.11; <jats:italic>P<\/jats:italic> = 0.03), shorter operation time (<jats:italic>SMD<\/jats:italic>, \u22120.55; 95% <jats:italic>CI<\/jats:italic>, \u22120.88 to \u22120.21; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), less blood loss (<jats:italic>SMD<\/jats:italic>, \u22121.72; 95% <jats:italic>CI<\/jats:italic>, \u22123.33 to \u22120.11; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and fewer complications (<jats:italic>OR<\/jats:italic>, \u22120.11; 95% <jats:italic>CI<\/jats:italic>, \u22120.16 to \u22120.07; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) than the EN group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the meta\u2010analysis showed that AP is found to be superior for nonunion of femoral shaft fractures in both intraoperatively (ie, shorter operation time and less blood loss) and postoperatively (ie, higher union rate, shorter union time, and lower complication rate). Overall, AP was superior to EN in the treatment of nonunion of femoral shaft fractures after intramedullary nailing (IMN).<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12580","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T07:12:33Z","timestamp":1577949153000},"page":"50-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparing Augmentative Plating and Exchange Nailing for the Treatment of Nonunion of Femoral Shaft Fracture after Intramedullary Nailing: A Meta\u2010analysis"],"prefix":"10.1111","volume":"12","author":[{"given":"Yao\u2010feng","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Surgery The Second Affiliated Hospital of Jiaxing University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery The Second Affiliated Hospital of Jiaxing University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong\u2010hai","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery The Second Affiliated Hospital of Jiaxing University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010kang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery The Second Affiliated Hospital of Jiaxing University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-6253","authenticated-orcid":false,"given":"Hui","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery The Second Affiliated Hospital of Jiaxing University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2008.07.017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199506000-00016"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-200207000-00005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199810000-00021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1757-7861.2009.00041.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-016-3207-2"},{"key":"e_1_2_6_8_1","first-page":"591","article-title":"Aseptic nonunion of a femoral shaft treated using exchange nailing","volume":"25","author":"Yu CW","year":"2002","journal-title":"Chang Gung Med J"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20090511-12"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-010-0679-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3181b8dafd"},{"key":"e_1_2_6_12_1","first-page":"668","article-title":"Exchanging reamed nailing versus augmentative compression plating with autogenous bone grafting for aseptic femoral shaft nonunion: a retrospective cohort study","volume":"49","author":"Ru JY","year":"2015","journal-title":"Acta Orthop Traumatol Turc"},{"key":"e_1_2_6_13_1","first-page":"249","article-title":"Augmentative compression plating versus exchanging reamed nailing for nonunion of femoral shaft fracture after intramedullary nailing: a retrospective cohort study","volume":"82","author":"Ru J","year":"2016","journal-title":"Acta Orthop Belg"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2514-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199707000-00026"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.00742"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(02)00191-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2016.06.003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5473-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-017-2773-0"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12257"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000035093.56096.3C"}],"container-title":["Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fos.12580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.12580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/os.12580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.12580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T23:32:57Z","timestamp":1693697577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/os.12580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/os.12580"],"URL":"https:\/\/doi.org\/10.1111\/os.12580","archive":["Portico"],"relation":{},"ISSN":["1757-7853","1757-7861"],"issn-type":[{"value":"1757-7853","type":"print"},{"value":"1757-7861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}