{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:58:41Z","timestamp":1783511921755,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The efficacy of ketorolac supplementation on pain control for knee arthroscopy remains controversial. We conduct a systematic review and meta\u2010analysis to explore the impact of ketorolac supplementation on pain intensity after knee arthroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through September 2018 for randomized controlled trials (RCTs) assessing the effect of ketorolac supplementation <jats:italic>vs<\/jats:italic> placebo on pain management after knee arthroscopy. This meta\u2010analysis is performed using the random\u2010effect model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten RCTs involving 402 patients are included in the meta\u2010analysis. Overall, compared with control group for knee arthroscopy, ketorolac supplementation is associated with notably reduced pain scores at 1\u2009h (<jats:italic>MD<\/jats:italic> = \u22120.66; 95% <jats:italic>CI<\/jats:italic> = \u22121.12 to \u22120.21; <jats:italic>P<\/jats:italic> = 0.004) and 2\u2009h (<jats:italic>MD<\/jats:italic> = \u22120.90; 95% <jats:italic>CI<\/jats:italic> = \u22121.74 to \u22120.07; <jats:italic>P<\/jats:italic> = 0.03), prolonged time for first analgesic requirement (<jats:italic>MD<\/jats:italic> = 1.94; 95% <jats:italic>CI<\/jats:italic> = 0.33 to 3.55; <jats:italic>P<\/jats:italic> = 0.02) and decreased number of analgesic requirement (<jats:italic>RR<\/jats:italic> = 0.41; 95% <jats:italic>CI<\/jats:italic> = 0.23 to 0.75; <jats:italic>P<\/jats:italic> = 0.003), but has no obvious impact on analgesic consumption (<jats:italic>MD<\/jats:italic> = \u22120.56; 95% <jats:italic>CI<\/jats:italic> = \u22121.14 to 0.02; <jats:italic>P<\/jats:italic> = 0.06), as well as nausea and vomiting (<jats:italic>RR<\/jats:italic> = 0.44; 95% <jats:italic>CI<\/jats:italic> = 0.12 to 0.21; <jats:italic>P<\/jats:italic> = 0.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ketorolac supplementation is effective to produce pain relief for knee arthroscopy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12608","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T05:07:48Z","timestamp":1582175268000},"page":"31-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of Ketorolac Supplementation on Pain Control for Knee Arthroscopy: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7836-2253","authenticated-orcid":false,"given":"Rui\u2010jie","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery 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Medical Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery the First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery the First Affiliated Hospital of Chongqing Medical University  Chongqing 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