{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:43:46Z","timestamp":1784601826418,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"This work was supported by the Nanjing Key Program of Medical Science and Technology Development","award":["ZKX14021"],"award-info":[{"award-number":["ZKX14021"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the clinical outcome and complications associated with use of free vascularized fibular graft (FVFG) in the resection and reconstruction of extremity osteosarcoma (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study recruiting a consecutive series of 18 patients who had undergone resection of extremity OS between May 2009 and June 2017 in our clinic center. Reconstruction of the bone defect with FVFG was performed for each patient. Surgery\u2010related complications and time of bone union were recorded at the follow\u2010up visit. The functional outcome of the reconstructed limb was assessed with the musculoskeletal tumor society (MSTS) scoring system. Patients were further classified into low extremity group and upper extremity group according to the tumor location. The Student t\u2010test was used to compare the surgical outcome between the two subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 11 males and seven females with an average age of 25.9\u2009\u00b1\u200914.2\u2009years. The mean length of the bone resection was 11.9\u2009\u00b1\u20094.1\u2009cm. The mean follow\u2010up duration was 3.1\u2009\u00b1\u20091.2\u2009years. As for tumor location, six cases were located in the femur, five in the tibia, four in the humerus, two in the ulna, and one in the radius. All the patients had successful graft healing at an average of 4.9\u2009months after surgery. At the 2\u2010year follow\u2010up, an excellent functional outcome was observed in 88.9% of the patients (n = 16). The mean score of MSTS was 27.0\u2009\u00b1\u20094.6. Screw loosening and autograft fracture were observed in one patient with femur tumor, who had a low MSTS score of 11. Besides, there were three cases with delayed incision healing. Patients with lower extremity OS were found to have significantly longer duration of hospital stay and more blood loss than those with upper extremity OS. The incidence of postoperative complication was higher in the lower extremity group but with marginal significance (0% <jats:italic>vs<\/jats:italic> 36.3%, <jats:italic>P<\/jats:italic> =\u20090.1). There was no significant difference regarding time to bone union and the functional outcome as indicated by MSTS score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FVFG technique can be effectively applied to the reconstruction of bone defects after OS resection with satisfactory functional outcome and low incidence of complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12646","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T04:29:39Z","timestamp":1589603379000},"page":"727-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Outcome of Free Vascularized Fibula Graft in the Surgical Treatment of Extremity Osteosarcoma"],"prefix":"10.1111","volume":"12","author":[{"given":"Leilei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing 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