{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:19:18Z","timestamp":1789823958977,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of combined use of tranexamic acid (TXA) and dexamethasone (DEX) for anti\u2010inflammatory and clinical outcomes after total hip arthroplasty (THA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 patients were included in this randomized, controlled study. Patients in the TXA\u2009+\u2009DEX group were administered TXA at a dose of 15 mg\/kg, which was repeated 3\u2009h after THA, and received 20\u2009mg DEX. In contrast, patients in the TXA group were administered TXA at a dose of 15 mg\/kg, which was repeated at 3\u2009h postoperatively. C\u2010reactive protein (CRP), interleukin\u20106 (IL\u20106) and pain levels, incidence of postoperative nausea and vomiting (PONV), total blood loss and transfusion rates, postoperative fatigue, range of motion (ROM), length of hospital stay (LOS), analgesic rescue and antiemetic rescue consumption, and complications were compared in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CRP and IL\u20106 levels were lower in the TXA\u2009+\u2009DEX group than in the TXA group (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) at 24\u2009h, 48\u2009h, and 72\u2009h postoperatively. Patients in the TXA\u2009+\u2009DEX group had lower pain scores at rest and walking at 24\u2009h postoperatively (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the TXA\u2009+\u2009DEX group, the incidence of PONV was lower (<jats:italic>P<\/jats:italic> = 0.005), postoperative fatigue (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was reduced, and analgesia and antiemetic rescue consumption were also reduced. The total blood loss, transfusion rate, LOS and hip ROM were similar in the two groups. There was no thrombosis, infection, or gastrointestinal bleeding in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to TXA alone, the combination of TXA\u2009+\u2009DEX can reduce postoperative inflammatory response, relieve pain, and reduce PONV and fatigue, without increasing the risk of complications. Therefore, the present study suggested that the combination of TXA\u2009+\u2009DEX is an effective and safe accelerated rehabilitation strategy for patients receiving primary unilateral THA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12664","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T05:52:02Z","timestamp":1588139522000},"page":"582-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Combined Application of Dexamethasone and Tranexamic Acid to Reduce the Postoperative Inflammatory Response and Improve Functional Outcomes in Total Hip Arthroplasty"],"prefix":"10.1111","volume":"12","author":[{"given":"Yu\u2010zhang","family":"An","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120  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