{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:37:28Z","timestamp":1753738648411,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Medical Science Research Fund of the State Planning Commission of Zhejiang Province","award":["2018ZA048"],"award-info":[{"award-number":["2018ZA048"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Congenital pain insensitivity is a rare genetic disease and its clinical manifestations are many. In orthopaedics, common complications of this disease include painless fracture and Charcot's arthropathy. We followed up a case of multiple fractures of the lower extremity in two years, during which time he came to the clinic for five painless fractures of the lower extremity in a total of six parts. A mutation was found on the NTKRI gene (chr1:156813923(hg19), NM_001007792.1: c.1221938C &gt; T). We have developed a combination of surgery and conservative treatments for his condition, focusing on the mental state of the child and considering comprehensive treatment to be the best option for this type of patient. Occult fractures caused by pain insensitivity are often treated only as fractures, however their complications require routine examination and cleaning, suitable protective shoes, splint fixation, stretching, guided exercise planning, and early treatment of injuries. Due to the risk of fracture in the future, it is important that parents pay attention to the behavior and psychology of the child, such as not letting the child participate in exercise with a risk of injury, protective measures while playing, engaging in psychological counseling, and inducing interest in mental activity. These interventions will play a very important role in preventing the recurrence of fracture.<\/jats:p>","DOI":"10.1111\/os.12676","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T06:41:31Z","timestamp":1587364891000},"page":"1010-1015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Conservative Treatment or Surgical Treatment: A Case Report and Literature Review of Multiple Fractures of the Lower Extremities in a Child with Insensitivity to Pain"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-9984","authenticated-orcid":false,"given":"Yi\u2010kang","family":"Yu","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University, Second Clinical Medical College of Zhejiang Chinese Medical University  Zhejiang China"},{"name":"Department of Orthopaedics Xinhua Hospital of Zhejiang Province, The Second Affiliated Hospital of Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2626-8833","authenticated-orcid":false,"given":"Dong\u2010peng","family":"Tu","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Second Clinical Medical College of Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xinhua Hospital of Zhejiang Province, The Second Affiliated Hospital of Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Second Clinical Medical College of Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Second Clinical Medical College of Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Second Clinical Medical College of Zhejiang Chinese Medical University  Zhejiang China"},{"name":"Department of Orthopaedics Xinhua Hospital of Zhejiang Province, The Second Affiliated Hospital of Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-193206000-00002"},{"key":"e_1_2_4_3_1","first-page":"1065","volume-title":"Peripheral Neuropathy","author":"Dyck PJ","year":"1993"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-0974-3"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.8.1652"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-485"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2014.02.014"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S188566"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32458"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.06.017"},{"key":"e_1_2_4_11_1","first-page":"87","article-title":"Percutaneous reduction with k\u2010wires of a bimalleolar salter harris iii: a case report","volume":"7","author":"Meccariello L","year":"2012","journal-title":"EBMJ"},{"key":"e_1_2_4_12_1","first-page":"6","article-title":"Supracondylar fractures of the humerus, gartland 3: pediatric urgency. 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