{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:01:09Z","timestamp":1790226069476,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the results of raloxifene for prevention of periprosthetic bone loss around the femoral stem in patients undergoing total hip arthroplasty (THA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2015 and May 2017, 240 female patients between 55 and 80\u2009years underwent primary THA and were randomly allocated to receive 60 mg raloxifene hydrochloride per day (treatment group, TG, n = 120) or placebo (control group, CG, n = 120) orally at bedtime using computer\u2010generated randomization sequence generation. Baseline data, the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), women's quality of life (QoL) score, bone mineral density (BMD) around the prosthesis, and adverse events were compared between the two groups. The measuring range of BMD around the prosthesis was divided into seven regions of interest (ROI). The sample size was calculated to detect a mean difference in BMD of 0.15 g\/cm<jats:sup>2<\/jats:sup> with a standard deviation (SD) of 0.3. The error was set at 0.05 and the power level at 90% with additional compensation for a possible dropout rate of 20%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 240 participants in the study up to 24\u2009months after THA. There were no significant differences in the mean BMD of all the zones between groups before surgery (all <jats:italic>P<\/jats:italic> &gt;\u20090.05). However, there were significant differences in the BMD of Gruen zones 4 and 7 between groups at 6\u2009months postoperatively (both <jats:italic>P<\/jats:italic> &lt;\u20090.05); there were significant differences in Gruen zones 1, 4, 6, and 7 at 12\u2009months postoperatively (all <jats:italic>P<\/jats:italic> &lt;\u20090.01); there were significant differences in Gruen zones 1, 2, 4, 6, and 7 at 24\u2009months postoperatively (all <jats:italic>P<\/jats:italic> &lt;\u20090.001). Patients taking raloxifene reported higher QoL scores, with better improvement in BMD in all areas except in zones 3 and 5 compared with the control group. There were no significant differences in WOMAC pain (<jats:italic>P<\/jats:italic> =\u20090.4045), WOMAC function (<jats:italic>P<\/jats:italic> =\u20090.4456) and women's QoL scores (<jats:italic>P<\/jats:italic> =\u20090.5983) between groups before surgery. However, WOMAC pain, WOMAC function and women's QoL score in the treatment group were significantly better at all time points (all <jats:italic>P<\/jats:italic> &lt;\u20090.05). Patients in the treatment group showed no increased adverse events, including cardiac events, stroke, venous thromboembolism, and gynecological cancer (all <jats:italic>P<\/jats:italic> &gt;\u20090.05), but did show decreased odds of breast cancer in comparison with those using a placebo (<jats:italic>P<\/jats:italic> =\u20090.0437).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Raloxifene can help inhibit bone loss around the prosthesis and improve the QoL of postmenopausal women after THA with no increased adverse events, and can even decrease the odds of breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12696","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T05:39:32Z","timestamp":1595223572000},"page":"1074-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Raloxifene Prevents Early Periprosthetic Bone Loss for Postmenopausal Women after Uncemented Total Hip Arthroplasty: A Randomized Placebo\u2010Controlled Clinical Trial"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-7537","authenticated-orcid":false,"given":"Long","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery China\u2013Japan Friendship Hospital, Peking Union Medical College, Chinese Academy of Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital of Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[{"name":"Bao Ding Maternal and Children Hospital  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan\u2010juan","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Surgery  81 Group Military Hospital of Chinese PLA Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Surgery  81 Group Military Hospital of Chinese PLA Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010sheng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery China\u2013Japan Friendship Hospital, Peking Union Medical College, Chinese Academy of Medical College  Beijing 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