{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:54:58Z","timestamp":1789512898363,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Objective<\/jats:title><jats:sec><jats:label\/><jats:p>To evaluate the effects of two fall\u2010prevention and anti\u2010osteoporotic protocols in elderly patients with osteopenia (OPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present randomized controlled study included patients with OPA (<jats:italic>n<\/jats:italic> =123). The age of these patients was \u226580\u2009years old, with the mean age of 83.54 \u00b1\u20092.99\u2009years, and the male\u2010to\u2010female ratio was 2.97:1.00. Fall\u2010prevention guidance was given to all patients. Patients in the experiment group (<jats:italic>n<\/jats:italic> =\u200962) orally received 600 mg\/d of calcium carbonate, 0.5 \u03bcg\/d of alfacalcidol, and 70 mg\/week of alendronate, while patients in the control group (<jats:italic>n<\/jats:italic> =\u200961) orally received 600 mg\/d of calcium carbonate and 0.5 \u03bcg\/d of alfacalcidol for 18\u2009months. The grip strength, gait speed, bone turnover markers, serum calcium, serum phosphorus, parathyroid hormone (PTH), and bone mineral density were measured, and the Timed Up and Go (TUG) test and the chair rising test (CRT) were performed. Falls, fragility fractures, medication compliance, and side effects of the drugs were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum levels of bone turnover markers (type I procollagen amino\u2010terminal peptide [P1NP], type I collagen carboxyl terminal peptide [\u03b2\u2010CTx], and osteocalcin [OC]) decreased, while the bone mineral density of the lumbar spine and bilateral femoral neck increased after treatment in the experiment group (<jats:italic>P<\/jats:italic> &lt;\u20090.05, <jats:italic>P<\/jats:italic> &lt;\u20090.01). The rate of change in bone mineral density of the bilateral femoral neck was higher in the experiment group than the control group (3.43% <jats:italic>vs<\/jats:italic> 0.03%, <jats:italic>P<\/jats:italic> &lt;\u20090.05; 2.86% <jats:italic>vs<\/jats:italic> \u22120.02%, <jats:italic>P<\/jats:italic> &lt;\u20090.01). After treatment, the proportion of patients with increased hip T scores in the experiment group (66.1%, 41\/62) was significantly higher than the proportion (35.0%, 21\/60) in the control group (<jats:italic>P<\/jats:italic> =\u20090.001). The incidence of fall decreased in both groups after treatment compared to that before treatment (54.8% <jats:italic>vs<\/jats:italic> 33.9% and 54.1% <jats:italic>vs<\/jats:italic> 36.7%, respectively; <jats:italic>P<\/jats:italic> &lt;\u20090.05). The incidence of fragility fractures was lower in the experiment group than the control group (8.1% <jats:italic>vs<\/jats:italic> 20.0%, <jats:italic>P<\/jats:italic> =\u20090.057). During the intervention period, the incidence of fragility fractures in patients who did not fall (3.8%, 3\/79) was significantly lower than that in patients who fell (32.6%, 14\/43) (<jats:italic>P<\/jats:italic> =\u20090.000). The risk of fragility fractures was significantly lower in patients who did not fall compared to patients who fell (relative risk: 0.117, 95% confidence interval: 0.035\u20130.384).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of alendronate sodium with alfacalcidol and calcium can significantly improve the bone mineral density of the lumbar spine and femoral neck. For older patients with OPA, subjectively paying attention to avoiding falls can significantly reduce the risk of fragility fractures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12701","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T03:24:20Z","timestamp":1591241060000},"page":"890-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Fall Prevention and Anti\u2010Osteoporosis in Osteopenia Patients of 80\u2009Years of Age and Older: A Randomized Controlled Study"],"prefix":"10.1111","volume":"12","author":[{"given":"Jian","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Geriatrics Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-861X","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China) Beijing institute of Otolaryngology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010zhao","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"569","article-title":"NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7\u201329, 2000: highlights of the conference","volume":"94","year":"2001","journal-title":"South Med J"},{"key":"e_1_2_6_3_1","first-page":"413","article-title":"Guidelines for diagnosis and treatment of primary osteoporosis","volume":"10","author":"China Medical Association of Osteoporosis and Bone Mineral Research","year":"2017","journal-title":"Chin J Osteoporosis Bone Miner Res"},{"key":"e_1_2_6_4_1","unstructured":"National Bureau of Statistics of China. 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