{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:49:48Z","timestamp":1773499788137,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the postoperative inflammation and pain response between medial pivot (MP) and posterior stabilized (PS) prostheses among total knee arthroplasty (TKA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted from January 2019 to May 2019 at the Affiliated Hospital of Qingdao University. The study included patients diagnosed with stage III or IV Kellgren\u2013Lawrence knee osteoarthritis (KOA) who had failed conservative treatment, had undergone no previous knee surgeries, had varus substantial deformities (11\u00b0\u201320\u00b0 deviation), and had received their first unilateral TKA. A total of 109 patients who underwent PS prosthesis TKA and 98 patients who underwent MP prosthesis TKA were continuously enrolled. Inflammation biomarkers, such as leukocyte (white blood cells), erythrocyte sedimentation rate (ESR), and C\u2010reactive protein (CRP), together with hemoglobin (Hb), the visual analog pain score (VAS) and range of motion (ROM) were compared between the two groups. The Student <jats:italic>t<\/jats:italic>\u2010test was applied to analyze continuous parameters, and the \u03c7<jats:sup>2<\/jats:sup>\u2010test was used for categorical parameters. The linear mixed model was used for the repeated measurement data from the follow\u2010up visits. Multivariate backward logistic and linear regression models were used to determine the factors potentially influencing prostheses and VAS scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All these enrolled patients were followed up at 2, 4, 7, and 30\u2009days after TKA. There were no significant differences between the PS group and the MP group in body mass index (BMI), gender, laterality, usage of nonsteroidal anti\u2010inflammatory drugs (NSAIDs) and opioids, and drain tube extubation time (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Compared with the PS group, the MP group were older (67.5\u2009years <jats:italic>vs<\/jats:italic> 65.4\u2009years), and had a higher mid\u2010vastus approach rate (67.3% <jats:italic>vs<\/jats:italic> 26.6%), a shorter tourniquet duration (68.3\u2009\u00b1\u200910.2 h <jats:italic>vs<\/jats:italic> 73.9\u2009\u00b1\u200911.2 h), a larger prosthetic pad (10.8\u2009\u00b1\u20091.2\u2009mm <jats:italic>vs<\/jats:italic> 10.4\u2009\u00b1\u20091.2\u2009mm), and a lower drain tube diversion volume (187.6\u2009\u00b1\u2009119.3 mL <jats:italic>vs<\/jats:italic> 234.0\u2009\u00b1\u2009155.7 mL). In the linear mixed model, MP prostheses had less CRP and ESR elevation and less Hb decrease than PS prostheses (<jats:italic>P<\/jats:italic> for group \u00d7 time\u2009&lt;\u20090.001). There were no significant differences in the changing trends between MP and PS prostheses by time for VAS scores and ROM. In the multivariate logistic regression model, MP prostheses showed significant differences compared with PS prostheses in treatment approach (odds ratio [<jats:italic>OR<\/jats:italic>] = 3.371, 95% confidence interval [<jats:italic>CI<\/jats:italic>]: 1.953\u20137.127; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), ultrasound treatment start time (<jats:italic>OR<\/jats:italic> = 2.669, 95% <jats:italic>CI<\/jats:italic>: 1.385\u20135.141; <jats:italic>P<\/jats:italic> = 0.003), and tourniquet duration (<jats:italic>OR<\/jats:italic> = 0.954, 95% <jats:italic>CI<\/jats:italic>: 0.925\u20130.984; <jats:italic>P<\/jats:italic> = 0.003). Higher VAS scores on the second day postoperatively were related to high VAS scores preoperatively, use of opioids, high drain tube diversion, long tourniquet duration, and long drain tube extubation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MP prostheses showed potential advantages compared with PS prostheses in TKA in inflammatory responses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12822","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T12:19:29Z","timestamp":1603455569000},"page":"1843-1853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Postoperative Effects between Medial Pivot Prosthesis and Posterior Stabilized Prosthesis"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8813-561X","authenticated-orcid":false,"given":"Zi\u2010an","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Joint Surgery The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department\u2009of Science and Technology Management Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010ning","family":"Yan","sequence":"additional","affiliation":[{"name":"School of\u2009Nursing Qingdao\u2009University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010yan","family":"Li","sequence":"additional","affiliation":[{"name":"School of\u2009Nursing Qingdao\u2009University  Qingdao 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