{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:30:29Z","timestamp":1788449429793,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to determine outcomes and complications in functional reconstruction of soft tissue defects after surgical resection for soft tissue sarcomas (STSs) of extremities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was performed on patients with STSs of extremities from May 2015 to April 2019 who underwent radical resection of STSs and reconstruction of soft tissue defect with free vascularized anterolateral thigh flap (FVALTP). A minimum 3\u2010month follow\u2010up was required for all the patients. Patient demographics and comorbidities, flap characteristics, postoperative complications, and time to heal were recorded. The functional outcomes of the reconstructed limbs were assessed by the Musculoskeletal Tumour Society\uff08MSTS\uff09 scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11 patients (four males and seven females) were included in the study. The mean age was 62\u2009years (range: 29\u201384\u2009years). The mean surface area was 151.4\u2009cm<jats:sup>2<\/jats:sup> (range: from 64 cm<jats:sup>2<\/jats:sup> to 418cm<jats:sup>2<\/jats:sup>). The mean operation time was 126 min (range: 95\u2013296\u2009min). The mean follow\u2010up was 17.5 months (range: 6\u201334 months). The mean score of MSTS at last follow\u2010up was 26.2 (range: 12\u201329). Incision healed by first intention in eight patients. Incision healed by second intention in three patients. A patient who had received preoperative radiotherapy experienced delayed union. After debridement, the patient successfully got union. Another two patients experienced marginal necrosis of flap due to vascular crisis. After 3\u2010week dressing changes, the patients also got satisfactory union. One case suffered from vascular crisis during surgery in which the procedure was changed into skin grafting to cover resection site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FVALTP technique can be effectively applied to the reconstruction of soft tissue defect after STSs resection. The short\u2010term follow\u2010up indicated satisfactory functional outcome and low incidence of previously known complications. It was necessary to further validate its efficacy in reconstruction of soft tissue defect after malignant extremity soft tissue sarcoma resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.12840","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T09:25:38Z","timestamp":1639387538000},"page":"215-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reconstruction of Soft Tissue Defect With a Free Vascularized Anterolateral Thigh Flap After Resection of Soft Tissue Sarcoma in Extremities"],"prefix":"10.1111","volume":"14","author":[{"given":"Jun","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-6048","authenticated-orcid":false,"given":"Shoufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1562::AID-CNCR2820400428>3.0.CO;2-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041866"},{"key":"e_1_2_6_4_1","first-page":"21","article-title":"Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow\u2010up","volume":"21","author":"Casali PG","year":"2010","journal-title":"Ann Oncol"},{"key":"e_1_2_6_5_1","first-page":"124","article-title":"The management of soft\u2010tissue sarcomas of the extremities","volume":"17","author":"Simon MA","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.02.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1471-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11367"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(03)00040-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200106000-00019"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(1999)19:5<232::AID-MICR5>3.0.CO;2-S"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.10.1393"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B6.19805"},{"key":"e_1_2_6_14_1","first-page":"739","article-title":"Treatment of osteogenic sarcoma. 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