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However, if the strain is too large or too small, the biological behavior of the cells involved in bone healing will be affected, resulting in non\u2010union or delayed healing. In this review, we summarize the current state of knowledge regarding the effect of strain on cells that play a role in the fracture\u2010healing process. Overall, the related literature suggests that selection of an adequate strain promotes fracture healing through the stimulation of angiogenesis and osteogenesis, along with inhibition of osteoclast differentiation and bone resorption. However, standardized methods for the application of mechanical stimulation are lacking, and a unified consensus on the mechanism by which strain promotes cell differentiation has not yet been reached. These issues, therefore, deserve further investigation.<\/jats:p>","DOI":"10.1111\/os.12885","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T06:57:10Z","timestamp":1611644230000},"page":"369-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of Mechanical Strain on Cells Involved in Fracture Healing"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4404-2731","authenticated-orcid":false,"given":"Zheng\u2010wei","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 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