{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:32Z","timestamp":1787015972144,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2021,5]]},"abstract":"\n Objective<\/jats:title>\n \n To assess and compare the performance of fluorine\u201018\u2010labeled fluorodeoxyglucose positron emission tomography (\n 18<\/jats:sup>\n F\u2010FDG\u2010PET\/ CT) and gallium\u201068\u2010labeled tetraazacyclododecanetetraacetic acid\u2010DPhe1\u2010Tyr3\u2010octreotate (\n 68<\/jats:sup>\n Ga\u2010 DOTATATE) PET\/CT in the targeted imaging of culprit tumors causing osteomalacia.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a clinical retrospective analysis. We analyzed 13 patients (five men, eight women; mean age, 49\u2009years; range, 19\u201355\u2009years) with suspicion of tumor\u2010induced osteomalacia (TIO) between March 2017 and October 2019. All patients underwent two functional imaging methods to locate the culprittumors. Studies were performed on a PET\/CT scanner. The injection doses of\n 18<\/jats:sup>\n F\u2010 FDG and\n 68<\/jats:sup>\n Ga\u2010DOTATATE were 0.5mCi\/kg and approximately 5.0mCi, respectively. In the two scans, the whole body was captured from head to toe 45 to 60\u2009min after intravenous tracer injection.\n 68<\/jats:sup>\n Ga\u2010DOTATATE PET\/CT and\n 18<\/jats:sup>\n F\u2010FDG PET\/CT imaging results locate culprit tumors according to the following criteria: (i) abnormal foci uptake concentration was observed locally, and the uptake level was higher than the background level of the right lobe of the liver; (ii) combined CT showed or did not have obvious abnormal density changes; and (iii) non\u2010specific ingestion lesions due to fracture, arthritis, necrosis of femoral head are excluded. Compared with the results of pathological examination and clinical follow\u2010up, the sensitivity, specificity and accuracy of\n 68<\/jats:sup>\n Ga\u2010DOTATATE PET\/CT imaging and\n 18<\/jats:sup>\n F\u2010FDG PET\/CT imaging for TIO were analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All patients had symptoms of osteomalacia and hypophosphatemia. The lag time (symptoms to PET diagnosis) ranged from 2 to 12\u2009years. There were eight cases of TIO patients and five cases of non\u2010TIO patients confirmed by surgery, pathology and follow\u2010up. Among the eight TIO patients, there were six cases (75.0%) of PMTs, one case (12.5%) of giant cell tumor, one case (12.5%) of hemangiopericutoma. Most (\n n<\/jats:italic>\n = 6, 75.0%) of the confirmed tumors in our patient population were in the lower extremities, followed by craniofacial regions (\n n<\/jats:italic>\n = 1, 12.5%), and torso (\n n<\/jats:italic>\n = 1, 12.5%), respectively. Among the five non\u2010TIO patients, there were two cases of Fanconi syndrome, one case of rickets, and two cases of sporadic osteomalacia hypophosphorus. The culprit tumors could be located either in the bone (\n n<\/jats:italic>\n = 5, 62.5%) or the soft tissue (\n n<\/jats:italic>\n = 3, 37.5%).\n 18<\/jats:sup>\n F\u2010FDG PET\/CT was able to localize the tumor in six (6\/13, 46.1%) patients.\n 68<\/jats:sup>\n Ga\u2010DOTATATE PET\/CT detected tumor in 8 (83.3%) of 13 patients. The sensitivity of\n 68<\/jats:sup>\n Ga\u2010DOTATATE PET\/CT imaging and\n 18<\/jats:sup>\n F\u2010FDG PET\/CT imaging in the evaluation of TIO in our patient population were 100% (8\/8)\n vs<\/jats:italic>\n 75% (6\/8). The specificity of the two different methods was 80% (4\/5). The overall accuracy was 92.3% (12\/13)\n vs<\/jats:italic>\n 76.9% (10\/13).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n 68<\/jats:sup>\n Ga\u2010DOTATATE PET\/CT is very effective in assessing hypophosphatemia patients with TIO typical symptoms compared with\n 18<\/jats:sup>\n F\u2010FDG. Therefore, in clinically suspected cases of hypophosphatemic osteomalacia,\n 68<\/jats:sup>\n Ga\u2010DOTATATE PET\/CT should be preferred as an imaging modality investigation to avoid delay in the treatment of this disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/os.12980","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T01:26:27Z","timestamp":1615512387000},"page":"791-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of\n \n 18<\/sup>\n F\u2010FDG PET\n <\/scp>\n \/\n CT<\/scp>\n and\n \n 68<\/sup>\n Ga\u2010DOTATATE PET\n <\/scp>\n \/\n CT<\/scp>\n in the Targeted Imaging of Culprit Tumors Causing Osteomalacia"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6799-2778","authenticated-orcid":false,"given":"Hao\u2010nan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of PET\u2010CT Diagnostic Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Tianjin 4th Center Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010song","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of PET\u2010CT Diagnostic Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010sheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of PET\u2010CT Diagnostic Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of PET\u2010CT Diagnostic Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of PET\u2010CT Diagnostic Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2105"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.245.5.492"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe030037"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010839"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-3971-x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002290"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.316"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP10151.OR"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ16-0587"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1642"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-213954"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020881"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000341"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.04.016"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0317-x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.01.001"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-3919.172344"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10010002"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0552"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.07.002"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04489-z"},{"key":"e_1_2_5_24_1","first-page":"301","article-title":"Diagnostic performance of (18) F\u2010FDG PET\/CT in infectious and inflammatory diseases according to published meta\u2010analyses","volume":"25","author":"Treglia G","year":"2019","journal-title":"Contrast Media Mol Imaging"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000460"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.12.1.35"}],"container-title":["Orthopaedic 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