{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:23:54Z","timestamp":1789874634545,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101366"],"award-info":[{"award-number":["81101366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515012176"],"award-info":[{"award-number":["2019A1515012176"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313640"],"award-info":[{"award-number":["2018A030313640"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical application and surgical efficacy of the chimeric perforator flap pedicled with the descending branch of the lateral circumflex femoral artery and the lateral thigh muscle flap for the reconstruction of the large area of deep wound in foot and ankle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 32 cases who underwent chimeric anterolateral thigh perforator flap to repair the large area of deep wound of the foot and ankle from January 2015 to December 2018 were retrospectively analyzed. The sizes of the defects ranged from 18 cm \u00d7 10 cm to 35 cm \u00d7 20 cm, with exposed tendon and bone and\/or partial defects and necrosis, contaminations, accompanied by different degrees of infection. Following the radical debridement and VSD, chimeric anterolateral thigh perforator flap was employed to repair the deep wounds according to the position, site and deep\u2010tissue injury of the soft\u2010tissue defects. The skin flap and muscle flap were fanned out on the wound, and single\u2010 or two\u2010staged split\u2010thickness skin grafting was performed on the muscle flap. The operation time and blood loss were recorded. The survival and healing conditions of the operational site with chimeric anterolateral thigh perforator flap were evaluated post\u2010operationally. Complications at both recipient site and donor site were carefully recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean time of the operation was 325.5 min and average blood loss was 424.8 mL. Among the 32 cases, two cases developed vascular crisis, which were alleviated with intensive investigation and treatment; Four cases suffered from partial necrosis of the flap or skin graft on the muscle flap or on the residual local wound, which were improved after treatment of further dressing change and skin grafting. Another four cases experienced post\u2010traumatic osteomyelitis accompanied by bone defect were treated with simple bone grafting or Mesquelet bone grafting at 6\u20138 months after wound healing. Postoperatively, the wounds were properly healed, and the infection was effectively controlled without sinus tract forming. Overall, all 32 cases received satisfactory efficacy, without influencing subsequent functional reconstruction, and observed infection during the 12\u201336 months post\u2010operational follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The chimeric perforator flap pedicled with the descending branch of the lateral circumflex femoral artery and the lateral thigh muscle flap provides an effective and relative safe procedure for the repair of a large area of deep wound in the foot and ankle, particularly with irregular defect or deep dead space.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13046","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T06:06:27Z","timestamp":1623996387000},"page":"1609-1617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Reconstruction of Large Area of Deep Wound in the Foot and Ankle with Chimeric Anterolateral Thigh Perforator Flap"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4703-7180","authenticated-orcid":false,"given":"Run\u2010guang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Foot and Ankle Surgery, Center for Orthopaedic Surgery the Third Affiliated Hospital of Southern Medical University  Guangzhou China"},{"name":"Orthopaedic Hospital of Guangdong Province  Guangzhou China"},{"name":"Academy of Orthopaedics, Guangdong Province  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases  Guangzhou China"},{"name":"Department of Orthopedics Linzhi People's Hospital  Linzhi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can\u2010jun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Center for Orthopaedic Surgery the Third Affiliated Hospital of Southern Medical University  Guangzhou China"},{"name":"Orthopaedic Hospital of Guangdong Province  Guangzhou China"},{"name":"Academy of Orthopaedics, Guangdong Province  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Linzhi People's Hospital  Linzhi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010jie","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology, Department of Orthopaedics Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology, Department of Orthopaedics Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010biao","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology, Department of Orthopaedics Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010wen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Center for Orthopaedic Surgery the Third Affiliated Hospital of Southern Medical University  Guangzhou China"},{"name":"Orthopaedic Hospital of Guangdong Province  Guangzhou China"},{"name":"Academy of Orthopaedics, Guangdong Province  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao\u2010hong","family":"Ren","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Traumatology, Department of Orthopaedics Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22399"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1677878"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519865625"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30556"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22014"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2018.01032"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.883963"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.09.031"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.12.035"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22494"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.10.027"},{"key":"e_1_2_5_13_1","first-page":"13","article-title":"Bone transport for treatment of traumatic composite tibial bone and soft tissue defects: any specific needs besides the Ilizarov technique?","volume":"2020","author":"Li R","year":"2020","journal-title":"Biomed Res Int"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(1999)19:5<232::AID-MICR5>3.0.CO;2-S"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001103"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2019.01.035"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005955"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.09.003"},{"key":"e_1_2_5_19_1","first-page":"CD012522","article-title":"Negative pressure wound therapy for open traumatic wounds","volume":"7","author":"Iheozor\u2010Ejiofor Z","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1687922"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2014.06.006"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(03)00046-4"},{"key":"e_1_2_5_23_1","first-page":"e21","article-title":"Versatility of the anterolateral thigh free flap: the four seasons flap","volume":"12","author":"Di Candia M","year":"2012","journal-title":"Eplasty"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22526"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199108000-00006"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30450"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2019.08.007"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-016-1802-y"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1601422"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2013.40.5.575"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/23320885.2019.1635023"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31826d1662"},{"key":"e_1_2_5_33_1","first-page":"814","article-title":"Clinical application effect of blood circulation enhancement technique in repairing large area of skin and soft tissue defects of extremities with super large free anterolateral thigh flap","volume":"35","author":"Gao QF","year":"2019","journal-title":"Zhonghua Shao Shang Za Zhi"}],"container-title":["Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.13046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/os.13046","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.13046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T05:08:44Z","timestamp":1693285724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/os.13046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,17]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/os.13046"],"URL":"https:\/\/doi.org\/10.1111\/os.13046","archive":["Portico"],"relation":{},"ISSN":["1757-7853","1757-7861"],"issn-type":[{"value":"1757-7853","type":"print"},{"value":"1757-7861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,17]]},"assertion":[{"value":"2021-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}