{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:47:26Z","timestamp":1791478046849,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2022,2]]},"abstract":"Objectives<\/jats:title>To investigate the effect of Jintiange capsule on acute bone atrophy (vertebral height, Cobb's angle, bone mineral density, and visual analog score (VAS) in patients with osteoporotic vertebral compression fracture.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 106 patients with osteoporotic vertebral compression fractures were selected and randomly divided into study and control group. Vertebral height ratio (VHR), Cobb's angle, bone mineral density (BMD), and VAS analyses were performed as study indexes. The study was performed from January 2019 to December 2019 as a double\u2010blind, randomized, controlled trial and all the participants were blinded throughout the study. There were 24 males and 29 females in the study group, with 14 cases of thoracic fractures and 39 cases of lumbar fractures. The age was 61\u201375\u2009years, with an average of 67.5 \u00b1\u20092.7\u2009years, and the course of disease was 1\u20139\u2009days, with an average of 2.7 \u00b1\u20090.5\u2009days. There were 22 males and 31 females in the control group, with 17 cases of thoracic fractures and 36 cases of lumbar fractures. Patients in the control group received conventional postoperative treatment, while patients in the study group were treated with Jintiange capsule. The treatment continued for 3\u2009months. The ages of the participants were from 60 to 70\u2009years, while the average ages of both groups were 67 \u00b1\u20092.8\u2009years and the study recruited participants of both sexes.<\/jats:p><\/jats:sec>Results<\/jats:title>The clinical efficacy, vertebral imaging indexes before and after treatment, as well as pain and daily activity dysfunction scores were compared. The effect of the Jintiange capsule was followed for 3\u2009months and both the groups were compared. The total effective score of the study group was significantly increased (90.6%) in contrast to the control group (67.9) and the P<\/jats:italic> value was less than the 0.5. The vertebral height and bone mineral density of the study group was significantly improved compared to the control group (P<\/jats:italic> <\u20090.034) using t<\/jats:italic>\u2010test. However, the Cobb's angle of the study group was significantly (P<\/jats:italic> <\u20090.047) lower than the control group using t\u2010test after the treatment. On the other hand, the VAS score and Oswestry score of the study group were significantly lower than control group at 1\u2009month and 3\u2009months after treatment (P<\/jats:italic> <\u20090.05). There was no significance difference (all P<\/jats:italic> >\u20090.05) in term of gender and ages in both the recruited groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>It can be concluded that Jintiange capsule can significantly improve the clinical efficacy rate, vertebral height, Cobb's angle, and bone mineral density, pain relief, and daily activity function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13121","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T18:17:33Z","timestamp":1640283453000},"page":"427-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Artificial Tiger Bone Powder (Jintiange Capsule\u00ae) on Vertebral Height Ratio, Cobb's Angle, Bone Mineral Density, and Visual Analog Score"],"prefix":"10.1111","volume":"14","author":[{"given":"Long\u2010jun","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The First People's Hospital of Dali City Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8545-1438","authenticated-orcid":false,"given":"Ji\u2010yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The First People's Hospital of Dali City Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-018-0839-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12439"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2221-6189.281312"},{"key":"e_1_2_8_5_1","first-page":"239","article-title":"Correlation between microangiopathy and bone mineral density in patients with type 2 diabetes","volume":"24","author":"Wang Y","year":"2018","journal-title":"Chin J Osteoporosis"},{"key":"e_1_2_8_6_1","first-page":"765","article-title":"Effect of Bushen Jiangu Decoction assisted vertebroplasty on bone mineral density and lumbar function in elderly patients with osteoporotic compression fracture","volume":"45","author":"Liu KC","year":"2018","journal-title":"Liaoning J Traditi Chin Med"},{"key":"e_1_2_8_7_1","first-page":"719","article-title":"Chinese herbal medicines for rheumatoid arthritis","volume":"36","author":"Huang C","year":"2018","journal-title":"Chin Arch Tradit Chin Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-05144-x"},{"key":"e_1_2_8_9_1","first-page":"693","article-title":"Treatment of severe osteoporotic vertebral compression fractures with internal medicine by unilateral approach in lateral decubitus position","volume":"35","author":"Zhao L","year":"2019","journal-title":"Chin J Trauma"},{"key":"e_1_2_8_10_1","first-page":"737","article-title":"Kyphoplasty with movement and secondary enlargement of balloon for compression fracture of vertebral body with im\u2010complete posterior wall","volume":"39","author":"Zhu D","year":"2019","journal-title":"Chin J Orthop"},{"key":"e_1_2_8_11_1","first-page":"483","article-title":"Earlier Vertebroplasty for osteoporotic thoracolumbar compression fracture may minimize the subsequent development of adjacent fractures: a retrospective study","volume":"21","author":"Yang CC","year":"2018","journal-title":"Pain Physician"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57355-1"},{"key":"e_1_2_8_13_1","first-page":"95","article-title":"The research progress of tiger bone and artificial tiger bone for the treatment of osteoporosis","volume":"16","author":"Zhao Y","year":"2012","journal-title":"Chin J Osteoporosis"},{"key":"e_1_2_8_14_1","first-page":"941","article-title":"Analysis of the curative effect of vertebroplasty with unilateral and bilateral hydraulic conveying high viscosity bone cement in the treatment of osteoporotic vertebral compression fracture","volume":"40","author":"Chen XW","year":"2019","journal-title":"Guangdong Med J"},{"key":"e_1_2_8_15_1","first-page":"272","article-title":"Changes in inflammatory factors in patients with osteoporotic vertebral compression fracture and influences of rehabilitation training on postoperative functional recovery and inflammation","volume":"18","author":"Yehong L","year":"2018","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_8_16_1","first-page":"355","article-title":"Progress of orthopaedic research in China over the last decade","volume":"22","author":"Li Q","year":"2020","journal-title":"Chin J Orthop Trauma"},{"key":"e_1_2_8_17_1","first-page":"63","article-title":"Effectiveness analysis of percutaneous kyphoplasty combined with zoledronic acid in treatment of primary osteoporotic vertebral compression fractures","volume":"22","author":"Huang ZF","year":"2019","journal-title":"Pain Physician"},{"key":"e_1_2_8_18_1","first-page":"2479","article-title":"Comparison of percutaneous kyphoplasty, zoledronic acid or both in the treatment of senile osteoporotic lumbar vertebral compression fractures","volume":"23","author":"Zhagn M","year":"2019","journal-title":"Chin J Tissue Eng Res"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24180"}],"container-title":["Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.13121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/os.13121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.13121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:58:11Z","timestamp":1693141091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/os.13121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/os.13121"],"URL":"https:\/\/doi.org\/10.1111\/os.13121","archive":["Portico"],"relation":{},"ISSN":["1757-7853","1757-7861"],"issn-type":[{"value":"1757-7853","type":"print"},{"value":"1757-7861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,22]]},"assertion":[{"value":"2020-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}