{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:14:49Z","timestamp":1782332089171,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the biomechanical effect of lateral inclination C<jats:sub>1<\/jats:sub> and C<jats:sub>2<\/jats:sub> pedicle screws on the atlantoaxial fixation through vitro human cadaveric study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2016 to December 2017, fresh\u2010frozen cadaveric cervical spines with intact ligaments from eight donated cadavers at an average age of 71.5 \u00b1\u200910.6\u2009years, comprising of six males and two females, were collected. There were no fracture and congenital malformation in all specimens according to the imaging examination. The range of motion (ROM) of the specimens were tested in their intact condition and destabilized condition. Next, the specimens were randomly divided into two groups to ensure no differences in sex and age: Group 1 was medial inclination C<jats:sub>1<\/jats:sub> pedicle screw and C<jats:sub>2<\/jats:sub> pedicle screws (C<jats:sub>1<\/jats:sub>MPS\u2010C<jats:sub>2<\/jats:sub>PS) and Group 2 was lateral inclination C<jats:sub>1<\/jats:sub> pedicle screw and C<jats:sub>2<\/jats:sub> pedicle screws (C<jats:sub>1<\/jats:sub>LPS\u2010C<jats:sub>2<\/jats:sub>PS). The ROM of the fixation scenarios were recorded. Thereafter, all the specimens with fixation constructs were tested for 1,000\u2009cycles of axial rotation and tensile loading to failure was carried out collinearly to the longitudinal axis of all the screws, the data were documented as screw pullout strength (SPS) in newtons. All the recorded data subjected to quantitative analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ROM of specimens was increased significantly in destabilized condition and significantly reduced in fixation condition compared with intact condition. In C<jats:sub>1<\/jats:sub>LPS\u2010C<jats:sub>2<\/jats:sub>PS groups, the C<jats:sub>1<\/jats:sub>\u2010C<jats:sub>2<\/jats:sub> cervical segment showed 3.96\u00b0 \u00b11.21\u00b0 and 3.75\u00b0 \u00b1\u20091.33\u00b0 in flexion and extension direction, 2.85\u00b0 \u00b1\u20090.91\u00b0 and 2.96\u00b0 \u00b1\u20090.71\u00b0 in right and left lateral bending, 2.20\u00b0 \u00b1\u20090.43\u00b0 and 2.15\u00b0 \u00b1\u20090.40\u00b0 in right and left axial rotation. In C<jats:sub>1<\/jats:sub>MPS\u2010C<jats:sub>2<\/jats:sub>PS groups, it showed 4.24\u00b0 \u00b11.31\u00b0 and 3.98\u00b0 \u00b1\u20091.21\u00b0 in flexion and extension direction, 2.76\u00b0 \u00b1\u20091.10\u00b0 and 3.23\u00b0 \u00b1\u20090.62\u00b0 in right and left lateral bending, 2.20\u00b0 \u00b1\u20090.46\u00b0 and 2.21\u00b0 \u00b1\u20090.42\u00b0 in right and left axial rotation. There was no statistically significant difference on ROM and screw pullout strengths (764.29 \u00b1\u2009129.00 N <jats:italic>vs<\/jats:italic> 714.55 \u00b1\u2009164.63 N) between the two groups. However, there was one specimen in the C<jats:sub>1<\/jats:sub>MPS\u2010C<jats:sub>2<\/jats:sub>PS group showing rupture the inferior wall of the left screw trajectory owing to the relatively thin posterior arch of the atlas, the screw pullout strength was significantly reduced (left pullout strength value: 430.5 N, right pullout strength value: 748.4 N). Therefore, in the case of the thin posterior arch of the atlas, the C<jats:sub>1<\/jats:sub>LPS\u2010C<jats:sub>2<\/jats:sub>PS group had strong long\u2010term biomechanics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The lateral inclination C<jats:sub>1<\/jats:sub> pedicle screw can achieve the same biomechanical strength as the traditional atlas pedicle screw. However, for the case where the posterior arch of the atlas is relatively thin, a lateral inclination C<jats:sub>1<\/jats:sub> pedicle screw is more suitable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13137","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T08:08:08Z","timestamp":1632125288000},"page":"2027-2033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biomechanical Effects of Lateral Inclination <scp>C<sub>1<\/sub><\/scp> and <scp>C<sub>2<\/sub><\/scp> Pedicle Screws on Atlantoaxial Fixation"],"prefix":"10.1111","volume":"13","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Spine Surgery Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-1594","authenticated-orcid":false,"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"27","article-title":"Imaging atlantooccipital and atlantoaxial traumatic injuries","volume":"89","author":"Havrda JB","year":"2017","journal-title":"Radiol Technol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-62515-7_9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2015.10.005"},{"key":"e_1_2_6_5_1","unstructured":"LacyJ BajajJ&GillisCCAtlantoaxial instability. 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