{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:07:54Z","timestamp":1790057274579,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of platelet\u2010rich plasma on tendon\u2010bone healing after anterior cruciate ligament reconstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 85 patients (range, 18\u201350\u2009years; mean age, 33.95 \u00b1\u200910.53\u2009years; male\/female, 49\/36) who underwent anterior cruciate ligament reconstruction using autologous hamstring tendons between August 2017 and June 2019 at our institute. The participants in the study group (n\u00a0=\u00a042) were injected with platelet\u2010rich plasma at both ends of the tendon graft, while those in the control group (n\u00a0=\u00a043) received an injection of normal saline. Magnetic resonance imaging signal\/noise quotient values of the femoral and tibial ends, knee Lysholm scores, and International Knee Documentation Committee scores were compared at 3, 6, and 12\u2009months postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The signal\/noise quotient values of the femoral and tibial ends in both groups were higher at 6\u2009months than at 3 and 12\u2009months postoperatively. The signal\/noise quotient values of the tibial end were significantly lower in the platelet\u2010rich plasma group than in the normal saline group at all follow\u2010up time points (<jats:italic>P<\/jats:italic> &lt;\u20090.05). The signal\/noise quotient values of the tibial and femoral ends in both groups were significantly different at 3, 6, and 12\u2009months postoperatively (<jats:italic>P<\/jats:italic> &lt;\u20090.05). Additionally, the signal\/noise quotient values of the tibia were significantly lower than those of the femur in both groups (<jats:italic>P<\/jats:italic> &lt;\u20090.05). The Lysholm and International Knee Documentation Committee scores were significantly better in the platelet\u2010rich plasma group than in the normal saline group only at 3\u2009months postoperatively. No complications, such as knee joint infection or vascular and nerve injuries, occurred in any of the 85 patients. The knee flexion of all patients were more than 90\u00b0, and the straight degree was 0\u00b0. No joint stiffness was observed in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platelet\u2010rich plasma can promote tendon\u2010bone healing in grafts and can improve early postoperative knee joint function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13175","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T10:17:18Z","timestamp":1638785838000},"page":"88-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Platelet\u2010Rich Plasma on Tendon\u2010Bone Healing After Anterior Cruciate Ligament Reconstruction"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-0915","authenticated-orcid":false,"given":"Rong\u2010jin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of TCM  Chengdu China"},{"name":"Department of Orthopedic Surgery Affiliated Zhongshan Hospital of Dalian University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010zhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chengdu Fifth People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010yi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Oncology Chengdu Fifth People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-4878","authenticated-orcid":false,"given":"Xian\u2010xiang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Affiliated Zhongshan Hospital of Dalian University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520908849"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653964"},{"key":"e_1_2_8_4_1","first-page":"629","article-title":"Repair of rotator cuff tendon defects in aged rats using a growth factor injectable gel scaffold","volume":"36","author":"Han B","year":"2020","journal-title":"Art Ther"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-019-01078-w"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.02.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2020.05.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S183842"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2019.01.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520927015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12509"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518757759"},{"key":"e_1_2_8_13_1","first-page":"535","article-title":"Co\u2010injection of human adipose stromal cells and rhBMP\u20102\/fibrin gel enhances tendon graft osteointegration in a rabbit anterior cruciate ligament\u2010reconstruction model","volume":"10","author":"Chen P","year":"2018","journal-title":"Am J Transl Res"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2020.0239.A"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34146"},{"key":"e_1_2_8_16_1","first-page":"4981","article-title":"Enhancement of tendonbone healing following rotator cuff repair using hydroxyapatite with TGFbeta1","volume":"17","author":"You X","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120576"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74341-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519849657"},{"key":"e_1_2_8_20_1","first-page":"1486","article-title":"Effect of autologous platelet\u2010rich plasma and gelatin sponge for tendon\u2010to\u2010bone healing after rabbit anterior cruciate ligament reconstruction","volume":"35","author":"Zhang M","year":"2019","journal-title":"Art Ther"},{"key":"e_1_2_8_21_1","first-page":"1204","article-title":"Anterior cruciate ligament reconstruction with platelet\u2010rich plasma: a systematic review of randomized control trials","volume":"36","author":"Davey MS","year":"2020","journal-title":"Art Ther"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465010290061401"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510368132"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-014-3302-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-4982-7"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2020.9111"},{"key":"e_1_2_8_27_1","first-page":"290","article-title":"Enveloping the tendon graft with periosteum to enhance tendon\u2010bone healing in a bone tunnel: a biomechanical and histologic study in rabbits","volume":"19","author":"Chen CH","year":"2003","journal-title":"Art Ther"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518769295"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02437-y"},{"key":"e_1_2_8_30_1","first-page":"50","article-title":"Comparison of magnetic resonance imaging findings in anterior cruciate ligament grafts with and without autologous platelet\u2010derived growth factors","volume":"26","author":"Radice F","year":"2010","journal-title":"Art Ther"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-4910-x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/230949901302100105"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511402662"},{"key":"e_1_2_8_34_1","first-page":"1712","article-title":"\"Ligamentization\" in hamstring tendon grafts after anterior cruciate ligament reconstruction: a systematic review of the literature and a glimpse into the future","volume":"29","author":"Pauzenberger L","year":"2013","journal-title":"Art Ther"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514561435"},{"key":"e_1_2_8_36_1","first-page":"1318","article-title":"Magnetic resonance imaging evaluation of the integration and maturation of semitendinosus\u2010gracilis graft in anterior cruciate ligament reconstruction using autologous platelet concentrate","volume":"26","author":"Figueroa D","year":"2010","journal-title":"Art Ther"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2492071651"}],"container-title":["Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.13175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/os.13175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.13175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:29:01Z","timestamp":1693196941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/os.13175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,6]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/os.13175"],"URL":"https:\/\/doi.org\/10.1111\/os.13175","archive":["Portico"],"relation":{},"ISSN":["1757-7853","1757-7861"],"issn-type":[{"value":"1757-7853","type":"print"},{"value":"1757-7861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,6]]},"assertion":[{"value":"2021-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}