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Femoral head collapse is a critical turning point in the development of ONFH and is related to the prognosis of patients. Early prevention and intervention help to preserve the hip joint and delay femoral head collapse. However, the mechanism of collapse still needs to be further studied because it is affected by different complex factors. This review discusses the underlying causes of femoral head collapse from two aspects: structural degradation and regional changes of biomechanical properties in the necrotic femoral head.<\/jats:p>","DOI":"10.1111\/os.13277","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T08:14:25Z","timestamp":1650528865000},"page":"831-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Role of Structural Deterioration and Biomechanical Changes of the Necrotic Lesion in Collapse Mechanism of Osteonecrosis of the Femoral Head"],"prefix":"10.1111","volume":"14","author":[{"given":"Peng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery The Affiliated Hospital of Southwest Medical University  Luzhou China"},{"name":"Institute of Orthopaedics,Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal 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