{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:06:18Z","timestamp":1780535178103,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772364"],"award-info":[{"award-number":["81772364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19411962600"],"award-info":[{"award-number":["19411962600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the diagnostic efficacy of triple\u2010phase bone scanning and the temporal impact of prosthesis implantation on the diagnostic efficacy of triple\u2010phase bone scanning for periprosthetic joint infection (PJI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were admitted to our hospital for joint pain and dysfunction after total joint arthroplasty between 2014 and 2020 were retrospectively included. Triple\u2010phase bone scanning was performed, and the blood pool images were evaluated to obtain the semi\u2010quantitative criteria. The patients were then grouped into six groups according to the time interval from index primary arthroplasty to triple\u2010phase bone scanning. We examined whether there were significant differences in sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 66 patients who underwent total hip arthroplasty (THA) and 74 patients who underwent total knee arthroplasty (TKA) were analyzed. No significant differences were observed between visual analysis and semi\u2010quantitative measurement in terms of sensitivity, specificity, PPV, NPV, and accuracy. For patients with a time interval from prosthesis implantation to bone scanning of &gt;1\u2009year, visual analysis had a higher PPV (100%) in patients who underwent THA and the use of semi\u2010quantitative criteria had a higher NPV (85.7%) in patients who underwent TKA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The semi\u2010quantitative criteria showed no advantages in the diagnosis of PJI. In addition, triple\u2010phase bone scanning demonstrated good clinical diagnostic efficacy when the time interval from prosthesis implantation to bone scanning was &gt;1\u2009year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13278","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T08:59:35Z","timestamp":1655197175000},"page":"1438-1446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Temporal Impact of Prosthesis Implantation and Semi\u2010Quantitative Criteria on the Diagnostic Efficacy of Triple\u2010Phase Bone Scanning for Periprosthetic Joint Infection"],"prefix":"10.1111","volume":"14","author":[{"given":"Feiyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai 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