{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:41:34Z","timestamp":1792593694714,"version":"4.5.0"},"reference-count":157,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Intervertebral disc degeneration (IVDD) is the most common contributor to low back pain (LBP). Recent studies have found that oxidative stress and reactive oxygen species (ROS) play an important role in IVDD. As a by\u2010product of aerobic respiration, ROS is mainly produced in the mitochondria by the electron transport chain and other mitochondrial located proteins. With the excessive accumulation of ROS, mitochondria are also the primary target of ROS attack in disc cells. A disrupted balance between intracellular ROS production and antioxidant capacity will lead to oxidative stress, which is the key contributor to cell apoptosis, cell senescence, excessive autophagy, and mitochondrial dysfunction. As the pivotal ingredient of oxidative stress, mitochondrial dysfunction manifests as imbalanced mitochondrial dynamics and dysregulated mitophagy. Mitochondria can alter their own dynamics through the process of fusion and fission, so that disabled mitochondria can be separated from the mitochondrial pool. Moreover, mitophagy participates by clearing these dysfunctional mitochondria. Abnormality in any of these processes either increases the production or decreases the clearance of ROS, leading to a vicious cycle that results in the death of intervertebral disc cells in large quantities, combined with degradation of the extracellular matrix and overproduction of matrix metalloproteinase. In this review, we explain the changes in mitochondrial morphology and function during oxidative stress\u2010mediated IVDD and highlight the important role of mitochondria in this process. Eventually, we summarize the IVDD therapeutic strategies targeting mitochondrial dysfunction based on current understanding of the role of oxidative stress in IVDD.<\/jats:p>","DOI":"10.1111\/os.13302","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T07:45:55Z","timestamp":1654674355000},"page":"1569-1582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Mitochondrial Dysfunction in Oxidative Stress\u2010Mediated Intervertebral Disc Degeneration"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1236-4461","authenticated-orcid":false,"given":"Dian\u2010Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Spine Centre Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huo\u2010Liang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Spine Centre Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9628-9213","authenticated-orcid":false,"given":"Wen\u2010Sheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Spine Centre Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4404-2731","authenticated-orcid":false,"given":"Zheng\u2010Wei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Dan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Spine Centre Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spine Centre Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Feng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Spine Centre Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei\u2010Sheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Spine Centre Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2007.08.001"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"34","article-title":"The role of Adipokines in intervertebral disc degeneration","volume":"6","author":"Sharma A","year":"2018","journal-title":"Med Sci"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182077122"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.00019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0056-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30480-X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30725-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000150833.93248.09"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2011.07.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199801010-00001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22789"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.09.019"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199104000-00010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5601593"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7346"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-015-1128-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2087-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.06.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2937-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22204"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2009.04.018"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181bc3e04"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0839-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.06.006"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-014-3630-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366330"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1309"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.05.013"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3802"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-2037-8"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2018"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v023a08"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22628"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v030a07"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165744"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.04.005"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5039"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.01.013"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00307-5"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.01.003"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.186841"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021121"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2012.12.002"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00149.2002"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401844200"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.011"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12051014"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00337"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.06.021"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X18500349"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3453926"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R900010200"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.6064\/2012\/857516"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.06.002"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2187-z"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020564"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.004"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01565"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504880112"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231031"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004374"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.05.009"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21077"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201609019"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200906083"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200704110"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.89"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.01.001"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3560"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07543-w"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.74"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0510-7"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11553"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155452"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.54"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19287-7"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201508099"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507943200"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20555"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.10.013"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvz106"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.08.011"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709111"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08828"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201610057"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0176-2"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1024-9"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.07.020"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201008084"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0470-7"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.129"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111559"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613040114"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.09.007"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.03.012"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14175-1"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051440"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201509003"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201007013"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32866"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.12.009"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-08-0607"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.11.010"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw189"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14533-4"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0037-z"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.733410"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.7.13005"},{"key":"e_1_2_9_110_1","first-page":"1","article-title":"Dimerization of mitophagy receptor BNIP3L\/NIX is essential for recruitment of autophagic machinery","volume":"17","author":"Marinkovi\u0107 M","year":"2020","journal-title":"Autophagy"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.014"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.031"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29684"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0331-2"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.10.039"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12779"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.01.018"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9474-y"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.06.163"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.30398"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.02.023"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0073-2"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.024"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0763-6"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.03.200"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.09.006"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.11.003"},{"issue":"9","key":"e_1_2_9_128_1","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a\u2010dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan N","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0085-5"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0448-z"},{"issue":"11","key":"e_1_2_9_131_1","first-page":"1146","article-title":"Resveratrol stimulates extracellular matrix synthesis in degenerative nucleus pulposus cells via upregulation of SIRT1","volume":"28","author":"Shen J","year":"2012","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology"},{"issue":"1","key":"e_1_2_9_132_1","first-page":"E215","article-title":"SIRT1 inhibits the catabolic effect of IL\u20101\u03b2 through TLR2\/SIRT1\/NF\u2010\u03baB pathway in human degenerative nucleus Pulposus cells","volume":"19","author":"Shen J","year":"2016","journal-title":"Pain Physician"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13903"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14125"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13111"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109592"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0173-3"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00414"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7656"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02362-1"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170615112158"},{"key":"e_1_2_9_142_1","article-title":"Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF\u2010kappa B pathway","volume":"2015","author":"Chen Y","year":"2015","journal-title":"Biomed Res Int"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165575"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1054-8"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00240"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102302"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769709097855"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-4798-3"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1038932"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2020.101559"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO03353G"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.07.018"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.06.088"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.04.064"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.024"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6632786"},{"key":"e_1_2_9_157_1","first-page":"6631562","article-title":"Quercetin alleviates intervertebral disc degeneration by modulating p38 MAPK\u2010mediated autophagy","volume":"2021","author":"Zhang S","year":"2021","journal-title":"Biomed Res Int"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3565127"}],"container-title":["Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.13302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/os.13302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/os.13302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T10:19:52Z","timestamp":1692785992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/os.13302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,8]]},"references-count":157,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/os.13302"],"URL":"https:\/\/doi.org\/10.1111\/os.13302","archive":["Portico"],"relation":{},"ISSN":["1757-7853","1757-7861"],"issn-type":[{"value":"1757-7853","type":"print"},{"value":"1757-7861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,8]]},"assertion":[{"value":"2021-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}