{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:55:01Z","timestamp":1789750501978,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873322"],"award-info":[{"award-number":["81873322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973888"],"award-info":[{"award-number":["81973888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030122"],"award-info":[{"award-number":["82030122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["2020\u2010JYB\u2010ZDGG\u2010142\u20101"],"award-info":[{"award-number":["2020\u2010JYB\u2010ZDGG\u2010142\u20101"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Although tongue manifestation is a vital component of Traditional Chinese Medicine (TCM), relevant research on patients with osteonecrosis of the femoral head (ONFH) is still lacking. This study will explore the characteristic tongue manifestation of ONFH patients to inform future research and clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cross\u2010sectional study. All ONFH patients meeting criteria and their clinical data were collected from the online China osteonecrosis of the femoral head database (CONFHD) since it was created. Organized tongue manifestations of eligible patients through the tongue manifestation acquisition instrument, including tongue shape, tongue color, tongue coating thickness, tongue coating color and tongue coating moisture. We used descriptive analysis for the general information while systematic clustering analysis for the better summary of tongue characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 375 ONFH patients were included with an average age of 46.3\u2009years. Most patients appeared with enlarged tongue body (54.4%), and the proportions of pale and red tongue (62.4%) were higher than others. Tongue coating were mainly showed as thick (64.5%), white (57.6%) and moist (79.7%). Comparison of tongue shape between different causes of ONFH had a significant statistically difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000). Tongue manifestations could be cluster analyzed into three categories which were matched into four TCM syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The tongue manifestation of ONFH patients has a significant change both in tongue body and coating, and different features may be related to the ONFH pathology. This study provides new and valuable tongue informations for a preliminary screening of ONFH patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13388","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T10:13:15Z","timestamp":1658916795000},"page":"2023-2030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tongue Manifestation in Patients with Osteonecrosis of the Femoral Head: A Cross\u2010sectional Study"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2545-8558","authenticated-orcid":false,"given":"Yan","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Minimally Invasive Arthrology The Third Affiliated Hospital of Beijing University of Chinese medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Dongfang Hospital Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxu","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Arthrology The Third Affiliated Hospital of Beijing University of Chinese medicine  Beijing China"},{"name":"Department of Orthopedics Fangshan Hospital Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Arthrology The Third Affiliated Hospital of Beijing University of Chinese medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongtian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Arthrology The Third Affiliated Hospital of Beijing University of Chinese medicine  Beijing 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