{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:47:24Z","timestamp":1769176044312,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Surgery"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Although widely used in clinical practice, vertebral augmentation procedure (VAP) for osteoporotic vertebral compression fracture (OVCF) is not supported. Recently, the effect of recombinant human parathyroid hormone (1\u201334) (rhPTH) has been paid great attention for its efficacy in anti\u2010osteoporosis and bone union. This study aims to explore the outcome of rhPTH on acute OVCF and compare it with VAP to clarify its therapeutic advantages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The retrospective study comprised 71 acute OVCF patients from January 2015 to March 2020: 22 received rhPTH treatment (rhPTH group) and 49 underwent VAP (VAP group). The rhPTH group was 15 women and seven men with an average of 76.18\u2009years, and the VAP group were 35 women and 14 men with an average of 73.63\u2009years. The thoracic\/lumbar vertebrae were 14\/8 in the rhPTH group and 29\/20 in the VAP group. The average follow\u2010up period was 14.05\u00a0months in the rhPTH group and 13.82\u00a0months in the VAP group. The two groups were assessed regarding the visual analog score (VAS), Oswestry Disability Index (ODI), OVCF bone union, bone mineral density (BMD), kyphotic angle (KA), anterior and posterior border height (ABH and PBH, respectively), adverse events and the health\u2010related quality of life assessed by short form\u201036 health survey scores (SF\u201036). Categorical variables were analyzed by chi\u2010square test and continuous variables between groups were analyzed by independent samples <jats:italic>t<\/jats:italic>\u2010test or Mann\u2013Whitney <jats:italic>U<\/jats:italic> test according to the normality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the follow\u2010up, the VAS was significantly lower in the rhPTH group than in the VAP group at month 3 (0.39\u2009\u00b1\u20090.6 <jats:italic>vs<\/jats:italic> 0.68\u2009\u00b1\u20090.651) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.047), month 6 (0.45\u2009\u00b1\u20090.60 <jats:italic>vs<\/jats:italic> 2.18\u2009\u00b1\u20091.22) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and month 12 (0.45\u2009\u00b1\u20090.60 <jats:italic>vs<\/jats:italic> 2.43\u2009\u00b1\u20091.49) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At month 12, the ODI was significantly lower in the rhPTH group (18.59\u2009\u00b1\u20093.33%) than in the VAP group (28.93\u2009\u00b1\u200916.71%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Bone bridge was detected on sagittal computed tomography images of all fractured vertebrae in the rhPTH group. The BMD was significantly higher in the rhPTH group (87.66\u2009\u00b1\u20095.91 Hounsfield units [HU]) than in the VAP group (68.15\u2009\u00b1\u200911.32HU) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There were no significant differences in the changes in KA, ABH, and PBH between groups (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The incidence of new OVCF was significantly lower in the rhPTH group than in the VAP group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.042). All scores of SF\u201036 were significantly higher in the rhPTH group than in the VAP group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In acute OVCF patients, rhPTH was better than VAP in increasing spinal BMD to promote OVCF healing, reduce new OVCF, and improve back pain, physical ability, and health\u2010related quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/os.13470","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T09:49:49Z","timestamp":1661507389000},"page":"2510-2518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of Recombinant Human Parathyroid Hormone versus Vertebral Augmentation Procedure on Patients with Acute Osteoporotic Vertebral Compression Fracture"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8941","authenticated-orcid":false,"given":"Pengguo","family":"Gou","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery The Fifth Affiliated Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Tianjin 4th Centre Hospital  Tianjin Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Fifth Affiliated Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Fifth Affiliated Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Fifth Affiliated Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Fifth Affiliated Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-8418","authenticated-orcid":false,"given":"Feng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The Fifth Affiliated Hospital of Shanxi Medical University  Taiyuan Shanxi 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